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FLASH GENE
Symbol CFAP70 contributors: - updated : 06-10-2020
HGNC name cilia and flagella associated protein 70
HGNC id 30726
Corresponding disease
SPGF41 spermatogenic failure 41
Location 10q22.2      Physical location : -
Synonym name
  • tetratricopeptide repeat protein 18
  • Synonym symbol(s) TTC18, SPGF41, FLJ12173, FLJ25765
    DNA
    TYPE functioning gene
    STRUCTURE 107.31 kb     27 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3705 - 1121 - 2019 31621862
    26 - 3468 - 929 - 2019 31621862
    27 - 3440 - 1051 - 2019 31621862
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus is important for its ciliary localization
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • CFAP70 bound tightly to the ciliary axoneme
  • basic FUNCTION
  • CFAP70 is a novel regulatory component of the ODA in motile cilia and flagella
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF41
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS