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FLASH GENE
Symbol CFAP69 contributors: mct - updated : 17-05-2018
HGNC name cilia and flagella associated protein 69
HGNC id 26107
Corresponding disease
SPGF24 spermatogenic failure 24
Location 7q21.13      Physical location : -
Synonym symbol(s) FLJ21062,C7orf63, FAP69, SPGF24
DNA
TYPE functioning gene
STRUCTURE 75.79 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3909 - 941 - 2008 18288132
23 - 3855 - 923 - 2008 18288132
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Olfactory (smell)olfactory bulb     Mus musculus
Reproductivemale systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Olfactoryolfactory receptor Mus musculus
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
text
  • localized to the midpiece of the flagellum
    • basic FUNCTION
  • role of CFAP69 in the olfactory system seems to be to allow the olfactory transduction machinery to work at a precisely regulated range of response kinetics for robust olfactory behavior
  • is necessary for flagellum assembly/stability, and required during spermiogenesis for sperm flagellum development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other epigenetic processes strongly influence CFAP69
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF24
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS