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FLASH GENE

Symbol

CETN3

contributors: mct - updated : 18-01-2011

HGNC name	centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
HGNC id	1868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q14.3      Physical location : 89.689.530 - 89.705.603
Synonym name	caltractin (20kD calcium-binding protein)
	centrin-3
	CDC31 yeast homolog
	EF-hand superfamily member
Synonym symbol(s)	HSCEN3, CEN3, aco93510.2, MGC12502, MGC138245

DNA

TYPE	functioning gene
STRUCTURE	16.08 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004365 5 - 997 NP_004356 19 167 - 1997 9256449

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Hearing/Equilibrium ear       highly Reproductive male system testis     highly Visual eye retina       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Homo sapiens Visual rod photoreceptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains

EF-hand, Ca2+ binding protein

HOMOLOGY

Homologene

FAMILY

EF-hand superfamily of Ca2+-binding proteins

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus,chromatin/chromosome,centromere
	intracellular,nucleus,chromatin/chromosome,kinetochore
text	distal lumen of centrioles
	associated with centrosome-related structures

basic FUNCTION	Ca(2+) sensor protein, involved in the early process of centriole assembly, as they are concentrated within the precursor structures of centriole/basal bodies
	able to bind strongly to a model target peptide (melittin), as well as to peptides derived from the protein XPC, with a moderate Ca(2+) dependence

CELLULAR PROCESS	cell cycle, division, mitosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the centrosome of the interphase cells and mitotic spindle poles at mitosis

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS