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FLASH GENE
Symbol CETN3 contributors: mct - updated : 18-01-2011
HGNC name centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
HGNC id 1868
Location 5q14.3      Physical location : 89.689.530 - 89.705.603
Synonym name
  • caltractin (20kD calcium-binding protein)
  • centrin-3
  • CDC31 yeast homolog
  • EF-hand superfamily member
  • Synonym symbol(s) HSCEN3, CEN3, aco93510.2, MGC12502, MGC138245
    DNA
    TYPE functioning gene
    STRUCTURE 16.08 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391807 5 similar to peptidyl-Pro cis trans isomerase LOC391808 5 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC391809 5 similar to 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) MGC48637 5q14.3 hypothetical protein MGC48637 COX7C 5q14 cytochrome c oxidase subunit VIIc LOC389308 5 similar to ribosomal protein L10a FLJ11292 5q14.3 hypothetical protein FLJ11292 RASA1 5q13.3 RAS p21 protein activator (GTPase activating protein) 1 CCNH 5q13.3-q14 cyclin H MGC33214 5q14.3 hypothetical protein MGC33214 MEF2C 5q14 MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) CETN3 5q14.3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast) LOC153364 5q14.3 similar to metallo-beta-lactamase superfamily protein like (XL884) RPC32 5q14.3 polymerase (RNA) III (DNA directed) (32kD) LOC116068 5q14.3 hypothetical protein LOC116068 MASS1 5q14.1 monogenic, audiogenic seizure susceptibility 1 homolog (mouse) LOC133790 5q14.3 similar to ribosomal protein S18, cytosolic [validated] - rat KIAA1376 LOC133789 5q14.3 similar to Rab5c protein LOC391810 5 similar to T-complex protein 1, eta subunit (TCP-1-eta) (CCT-eta) (HIV-1 Nef interacting protein) LOC391811 5 similar to DNA polymerase delta subunit 2 NR2F1 5q14 nuclear receptor subfamily 2, group F, member 1 LOC389309 5 LOC389309 DKFZP564D172 5q15 hypothetical protein DKFZp564D172 FLJ25680 5q15 hypothetical protein FLJ25680 FLJ12078 5q15 hypothetical protein FLJ12078 KIAA0825 5q15 KIAA0825 protein MGC34713 5q15 hypothetical protein MGC34713 DKFZp761C121 5q15 hypothetical protein DKFZp761C121 FLJ22344 5q15 hypothetical protein FLJ22344 LOC389310 5 LOC389310 FLJ25333 5q15 hypothetical protein FLJ25333 KIAA0372 5q13-q15 hypothetical protein FLJ25333 DKFZp313G1735 5q15 hypothetical protein DKFZp313G1735 LOC285601 5q15 seven transmembrane helix receptor LOC285601 LOC317671 5q15 LOC317671 SPATA9 5q15 spermatogenesis associated 9 RHOBTB3 5q21.2 Rho-related BTB domain containing 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 997 19 167 - 1997 9256449
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • EF-hand, Ca2+ binding protein
  • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily of Ca2+-binding proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • distal lumen of centrioles
  • associated with centrosome-related structures
  • basic FUNCTION
  • Ca(2+) sensor protein, involved in the early process of centriole assembly, as they are concentrated within the precursor structures of centriole/basal bodies
  • able to bind strongly to a model target peptide (melittin), as well as to peptides derived from the protein XPC, with a moderate Ca(2+) dependence
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the centrosome of the interphase cells and mitotic spindle poles at mitosis
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS