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FLASH GENE
Symbol CETN3 contributors: mct - updated : 18-01-2011
HGNC name centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
HGNC id 1868
Location 5q14.3      Physical location : 89.689.530 - 89.705.603
Synonym name
  • caltractin (20kD calcium-binding protein)
  • centrin-3
  • CDC31 yeast homolog
  • EF-hand superfamily member
  • Synonym symbol(s) HSCEN3, CEN3, aco93510.2, MGC12502, MGC138245
    DNA
    TYPE functioning gene
    STRUCTURE 16.08 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 997 19 167 - 1997 9256449
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • EF-hand, Ca2+ binding protein
  • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily of Ca2+-binding proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • distal lumen of centrioles
  • associated with centrosome-related structures
  • basic FUNCTION
  • Ca(2+) sensor protein, involved in the early process of centriole assembly, as they are concentrated within the precursor structures of centriole/basal bodies
  • able to bind strongly to a model target peptide (melittin), as well as to peptides derived from the protein XPC, with a moderate Ca(2+) dependence
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the centrosome of the interphase cells and mitotic spindle poles at mitosis
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS