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FLASH GENE
Symbol CETN1 contributors: mct - updated : 11-07-2012
HGNC name centrin, EF-hand protein, 1
HGNC id 1866
Location 18p11.32      Physical location : 580.368 - 581.524
Synonym name
  • caltractin (20kD calcium-binding protein), isoform 2
  • calcium binding protein
  • centrin-1
    • Synonym symbol(s) CALT2, CEN1, CETN
    DNA
    TYPE functioning gene
    STRUCTURE 1.16 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure intronless
    MAPPING cloned Y linked N status confirmed
    Map see TYMS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1161 - 172 - 2006 16760425
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemplacenta   
     male systemtestis   
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    Reproductiveciliated cell Homo sapiens
    Reproductivegerm cell Homo sapiens
    Reproductivesperm cell Homo sapiens
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative EF-hand calcium binding domain
    • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily of Ca2+-binding proteins
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • centrosome during interphase, redistributed to spindle poles at the beginning of mitosis
  • associated with centrosome-related structures
  • co-localizes with GRK5, TUBG1, and pericentrin in centrosomes
    • basic FUNCTION
  • plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the centrosome of interphase cells and of mitotic spindle poles at mitosis
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • cooperate with CP110 and calmodulin to regulate progression through cytokinesis
  • assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein
  • interacting with SUMO-2/3 (possible role of calcium in modulating the CETN1-SUMO-2/3 interaction)
    • cell & other
    REGULATION
    Other phosphorylated during the cell cycle and play a role in centriole separation preceding centrosome duplication
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS