basic FUNCTION
| catalyzing the hydrolysis of ester and amide-bond containing drugs such as temocapril p-nitrophenyl-acetate, also hydrolyzing long chain acyl-CoA |
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putatively functioning as a blood-brain barrier to protect the CNS from ester or amide compounds |
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involved in metabolic activation of a variety of prodrugs into active derivatives and plays an important role in pharmacokinetics |
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governing both metabolic deactivation and activation of numerous therapeutic agents |
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in the hepatocytes, potentially regulates the synthesis of bile acids and thus the removal of cholesterol from the body (Zhao 2005) |
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key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs  |
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CES1 and CES2 are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals  |
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expression and activity of CES1, CES2 in human induced pluripotent stem (iPS) cell-derived enterocytes are more similar to the human small intestine compared with Caco-2 cells  |