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FLASH GENE
Symbol CERS5 contributors: mlc/np - updated : 30-06-2012
HGNC name ceramide synthase 5
HGNC id 23749
Location 12q13.13      Physical location : -
Synonym name
  • LAG1 longevity assurance homolog 5 (S. cerevisiae)
  • LAG1 homolog, ceramide synthase 5 (S. cerevisiae)
  • Synonym symbol(s) Trh4, MGC45411, FLJ25304, LASS5
    DNA
    TYPE functioning gene
    STRUCTURE 37.52 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1986 45 392 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunespleen    
    Nervousbrain    
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one homeobox DNA-binding domain
  • one TLC (TRAM/LAG1/CLN8) domain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Lass5 (76.5pc)
    homolog to chicken LASS5 (77.4pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • nuclear membrane
  • basic FUNCTION
  • having dihydro ceramide synthase activity
  • upon overexpression, is involved in the production of sphingolipids containing mainly one fatty acid donor in a fumosin B1-independent manner
  • regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA
  • interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid biosynthesis
    a component
  • constitutive heterodimer comprising CERS5 and CERS2, and the activity of CERS2 depends on the catalytic activity of CERS5
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer tissue compared with normal colorectal mucosa
    constitutional     --low  
    attenuated ceramide accumulation and hypoxia/reoxygenation-induced BAX translocation to mitochondria
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS