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FLASH GENE
Symbol CERS2 contributors: mct - updated : 03-01-2008
HGNC name LAG1 homolog, ceramide synthase 2
HGNC id 14076
Location 1q21.2      Physical location : -
Synonym name
  • LAG1 longevity assurance homolog 2 (S. cerevisiae)
  • L3 pigment
  • tumor metastasis-suppressor gene 1 protein
  • Synonym symbol(s) L3, SP260, TMSG1, FLJ10243, L3, MGC987
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text 11 alternative transcripts encoding altogether 7 distinct proteins (ACE/NCBI)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2505 44 380 - Ewing (2007)
    11 - 2465 44 380 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     parathyroid   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast longevity assurance lag1
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • may playing a role in the regulation of cell growth
  • regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA
  • interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner
  • important role for the CERS genes CERS2, CERS6) in breast cancer etiology or diagnosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constitutive heterodimer comprising CERS5 and CERS2, and the activity of CERS2 depends on the catalytic activity of CERS5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS