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FLASH GENE
Symbol CERK contributors: mct - updated : 12-09-2007
HGNC name ceramide kinase
HGNC id 19256
Location 22q13.31      Physical location : 47.080.307 - 47.134.152
Synonym name lipid kinase LK4
Synonym symbol(s) hCERK, FLJ23239, FLJ21430, KIAA1646, LK4
DNA
TYPE functioning gene
STRUCTURE 53.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4457 - 537 - Pettus
- - 3040 - 201 - Pettus
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrainmidbrainsubstantia nigra  
 ganglia    
Visualeyelens   
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal pleckstrin homology (PH) domain (essential for CERK activity, binding to phosphatidylinositol phosphates and localisation to the golgi and plasma membranes) (Don 2009)
  • a calmodulin binding motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text PH domain is essential for localisation to the golgi and plasma membranes (Don 2009)
    basic FUNCTION
  • playing a role in arachidonic acid release and production of eicosanoids
  • in mast cell degranulation CERK acts downstream of CALM1, similar to CALM1-dependent protein kinase II, which had been assumed to be the main target of CALM1 in mast cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text involved in lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by calmodulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS