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FLASH GENE
Symbol CERK contributors: mct - updated : 12-09-2007
HGNC name ceramide kinase
HGNC id 19256
Location 22q13.31      Physical location : 47.080.307 - 47.134.152
Synonym name lipid kinase LK4
Synonym symbol(s) hCERK, FLJ23239, FLJ21430, KIAA1646, LK4
DNA
TYPE functioning gene
STRUCTURE 53.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MRPS18CP6 22q13.31 mitochondrial ribosomal protein S18C pseudogene 6 DKFZp761O17121 22q13.31 hypothetical protein DKFZp761O17121 LOC129186 22q13.31 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC388910 22 LOC388910 ARHGAP8 22q13.31 Rho GTPase activating protein 8 LOC112885 22q13.31 hypothetical protein BC012187 NUP50 22q13.31 nucleoporin 50kDa KIAA0930 22q13.31 nucleoporin 50kDa UPK3A 22q13.31 uroplakin 3A FLJ20635 22q13 hypothetical protein FLJ20635 SMC1L2 22q13.31 SMC1 structural maintenance of chromosomes 1-like 2 (yeast) DKFZP566F0546 22q13.31 DKFZP566F0546 protein FBLN1 22q13.31 fibulin 1 LOC388911 22 LOC388911 E46L 22q13.31 LOC388911 LOC388912 22 LOC388912 FLJ10945 22q13.31 hypothetical protein FLJ10945 LOC388913 22 similar to seroreactive antigen BMN1-2 LOC150381 22q13.31 hypothetical protein LOC150381 PPARA 22q13.3 peroxisome proliferative activated receptor, alpha MGC2452 22q13.31 hypothetical protein MGC2452 LOC150383 22q13.31 similar to RIKEN cDNA 2210021J22 PKDREJ 22q13.32 polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin)-like FLJ20699 22q13 hypothetical protein FLJ20699 GTSE1 22q13.2-q13.3 G-2 and S-phase expressed 1 FLJ10140 22q13 hypothetical protein FLJ10140 CELSR1 22q13.32 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) KIAA0767 22q13.31 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) CERK 22q13.31 ceramide kinase C22orf4 22q13.3 chromosome 22 open reading frame 4 LOC391338 22 similar to 60S ribosomal protein L10 (QM protein homolog) LOC388914 22 LOC388914 LOC284931 22q13.32 hypothetical LOC284931 LOC388915 22 LOC388915 LOC388916 22 LOC388916 CLONE25003 22q13.32 hypothetical protein CLONE25003
RNA
TRANSCRIPTS type messenger
text two isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4457 - 537 - Pettus
- - 3040 - 201 - Pettus
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrainmidbrainsubstantia nigra  
 ganglia    
Visualeyelens   
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal pleckstrin homology (PH) domain (essential for CERK activity, binding to phosphatidylinositol phosphates and localisation to the golgi and plasma membranes) (Don 2009)
  • a calmodulin binding motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text PH domain is essential for localisation to the golgi and plasma membranes (Don 2009)
    basic FUNCTION
  • playing a role in arachidonic acid release and production of eicosanoids
  • in mast cell degranulation CERK acts downstream of CALM1, similar to CALM1-dependent protein kinase II, which had been assumed to be the main target of CALM1 in mast cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text involved in lipid transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by calmodulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS