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FLASH GENE

Symbol

CERK

contributors: mct - updated : 12-09-2007

HGNC name	ceramide kinase
HGNC id	19256

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.31      Physical location : 47.080.307 - 47.134.152
Synonym name	lipid kinase LK4
Synonym symbol(s)	hCERK, FLJ23239, FLJ21430, KIAA1646, LK4

DNA

TYPE	functioning gene
STRUCTURE	53.00 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two isoforms

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CERK variant 1 - - 4457 isoform a - 537 - Pettus CERK variant 2 - - 3040 isoform b - 201 - Pettus

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine parathyroid       highly   thyroid       highly Lymphoid/Immune lymph node       highly Nervous brain midbrain substantia nigra       ganglia         Visual eye lens

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal pleckstrin homology (PH) domain (essential for CERK activity, binding to phosphatidylinositol phosphates and localisation to the golgi and plasma membranes) (Don 2009)
	a calmodulin binding motif

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
text	PH domain is essential for localisation to the golgi and plasma membranes (Don 2009)

basic FUNCTION	playing a role in arachidonic acid release and production of eicosanoids
	in mast cell degranulation CERK acts downstream of CALM1, similar to CALM1-dependent protein kinase II, which had been assumed to be the main target of CALM1 in mast cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	involved in lipid transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

calmodulin

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS