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FLASH GENE
Symbol CER1 contributors: mct - updated : 10-07-2014
HGNC name cerberus 1 homolog, cysteine knot superfamily (Xenopus laevis)
HGNC id 1862
Corresponding disease
DEL9P chromosome 9p distal deletion
Location 9p22.3      Physical location : 14.719.733 - 14.722.715
Synonym name cerberus related 1
Synonym symbol(s) DAND4, MGC119894, MGC119895, MGC96951
DNA
TYPE functioning gene
STRUCTURE 2.98 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure three TCF/LEF-binding sites within the promoter
MAPPING cloned Y linked N status provisional
Map pter - D9S274 - CER1 - D9S156 - cen
Authors Lah (99)
Physical map
LOC392286 9 similar to chromosome 15 open reading frame 12; mitochondrial ribosomal protein S4 LOC340479 9p23 similar to A-kinase anchor protein 8; A-kinase anchor protein, 95kDa TYRP1 9p23 tyrosinase-related protein 1 LOC286343 9p22.3 similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed TDPX2 9p22 thioredoxin-dependent peroxide reductase 2 (thiol-specific antioxidant 2, proliferation-associated gene B) MPDZ 9p24-p22 multiple PDZ domain protein LOC347193 9p22.3 similar to Pescadillo homolog 1 LOC138864 9p22.3 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d NFIB 9p24.1 nuclear factor I/B ZDHHC21 9p22.3 zinc finger, DHHC domain containing 21 CER1 9p23-p22 cerberus 1 homolog, cysteine knot superfamily (Xenopus laevis) FLJ25461 9p22.3 hypothetical protein FLJ25461 LOC158222 9p22.2 lactate dehydrogenase pseudogene LOC389705 9 similar to 2700029M09Rik protein LOC353329 9p22.2 PC4 and SFRS1 interacting protein pseudogene C9orf52 9p22.2 chromosome 9 open reading frame 52 LOC286348 9p22.2 similar to 60S ribosomal protein L7 SNAPC3 9pter small nuclear RNA activating complex, polypeptide 3, 50kDa PSIP2 9 PC4 and SFRS1 interacting protein 2 LOC347195 9p22.2 similar to Ferritin heavy chain (Ferritin H subunit) FLJ39267 9p22.2 myosin tail domain-containing protein MGC24103 9p22.2 hypothetical protein MGC24103 C9orf39 9p22.2-p22.1 chromosome 9 open reading frame 39 SH3GL2 9p22 SH3-domain GRB2-like 2 ADAMTSL1 9p22.1-p21.3 ADAMTS-like 1 FLJ35283 9p22.1 hypothetical protein FLJ35283 MGC35182 9p22.1 hypothetical protein MGC35182 PSMC3P 9p proteasome (prosome, macropain) 26S subunit, ATPase, 3 pseudogene RRAGA 9p21.3 Ras-related GTP binding A FAM29A 9p22.1 family with sequence similarity 29, member A ADFP 9p23-p22 adipose differentiation-related protein LOC253482 9p21.3 similar to 40S ribosomal protein S6 (Phosphoprotein NP33)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1206 - 267 - 1999 10049596
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion
at STAGE
Text stem (ES) cells in the undifferentiated state and in the early endodermal lineage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine conserved cysteines and C-terminal cysteine knot-like domain (CTCK)
HOMOLOGY
interspecies homolog to Xenopus laevis
Homologene
FAMILY
  • member of cysteine knot superfamily
  • DAN domain (DAND) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • secreted cytokine, potentially involved in anterior neural induction and somite formation during mouse development
  • bone morphogenetic protein antagonist
  • inhibit NODAL signaling through ACVR1B (ALK4) or ACVR1C (ALK7) to SMAD2 or SMAD3
  • Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo (pMID: 19247954)
  • HHEX and CER1 mediate the SOX17 pathway for cardiac mesoderm formation in embryonic stem cells
  • profoundly suppresses migration, invasion, and colony forming ability of Nodal expressing and Nodal supplemented breast cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • potentially involved in ? anteroposterior and left-right (L/R) asymetry
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bone morphogenetic proteins
  • common target of WNT and NODAL signaling pathways in embryonic stem cells
  • transient inhibition of NODAL by CER1 induces Brahma-associated factor 60c (SMARCD3)
  • APLNR controls a regulatory CER1-SMARCD3 pathway in pluripotent stem cell cardiomyogenesis (pMID: 23787002)
  • LHX2 attenuates BMP and WNT signaling by promoting expression of the BMP and WNT antagonist CER1, to inhibit non-neural differentiation
  • binds NODAL with high affinity and specificity, blocks binding of NODAL to its signaling partners, and inhibits NODAL signaling
  • cell & other
    REGULATION
    induced by HH
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL9P
    Susceptibility to osteoporosis
    Variant & Polymorphism other CER1 variations seem to play a significant role in the determination of osteoporosis and a potential predictive role, in postmenopausal osteoporotic women
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    asymetriclly expressed in mice