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FLASH GENE
Symbol CEP97 contributors: mct - updated : 06-03-2018
HGNC name centrosomal protein 97kDa
HGNC id 26244
Location 3q12.3      Physical location : 101.443.493 - 101.486.181
Synonym name leucine-rich repeats and IQ motif containing 2
Synonym symbol(s) LRRIQ2, FLJ23047, FLJ26462, 2810403B08Rik
DNA
TYPE functioning gene
STRUCTURE 46.46 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 7516 - 806 - 2012 21620453
11 - 7693 96.9 865 - 2012 21620453
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Reproductivefemale systembreastmammary gland moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six LRR (leucine-rich) repeats
  • one IQ domain
  • HOMOLOGY
    interspecies homolog to rattus Cep97 (79.3 pc)
    homolog to murine Cep97 (77.7 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • collaborating with CEP110, being involved in the suppression of a cilia assembly program
  • required for correct spindle formation and having a role in cytokinesis
  • required for recruitment of CEP110 to the centrosome
  • CEP97 and other genes involved in regulation of cilia assembly may accelerate our understanding of human ciliary diseases, including renal disease and retinal degeneration (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CALM1 and CEP110
  • recruits CP110 to centrosomes (
  • KIF24 specifically interacts with CCP110 and CEP97, centrosomal proteins that play a role in regulating centriolar length and ciliogenesis
  • centriole elongation requires POC5 and is restricted by CCP110 and CEP97
  • TTBK2 has the potential to effectively phosphorylate CEP164 and CEP97 and inhibits the interaction between CEP164 and its binding partner DVL3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner
  • role for CEP152 in controlling centriole length in germline and somatic tissue, functioning via the centriole protein CEP97
  • interaction of CEP104 with CCP110, CEP97, end-binding (EB) protein, and tubulin
  • both endogenous CCP110 and CEP97 were able to bind to both SALL1FL and SALL1 mutant
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS