SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
text
| centrosomal protein  |
|
CEP63 and CEP152 co-localize in a discrete ring around the proximal end of the parental centriole  |
basic FUNCTION
| coordinates centrosome-dependent assembly of spindle structures  |
|
loss of CEP63 may contribute to the occurrence of genome instability typical of aggressive cancers  |
|
centrosomal recruitment factor for CDK1 essential for mitotic entry, providing a physical link between the centrosome and the cell-cycle machinery  |
|
CEP152 and CEP63 are essential for maintaining normal centrosome numbers in cells  |
|
CEP63 functions to ensure that centriole duplication occurs reliably in dividing mammalian cells  |
|
centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response  |
|
is required for maintaining normal centriole duplication and control of cell cycle progression  |
|
is likely particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated  |