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FLASH GENE
Symbol CEP350 contributors: mct - updated : 26-06-2018
HGNC name centrosomal protein 350kDa
HGNC id 24238
Location 1q25.2      Physical location : 179.923.907 - 180.084.014
Synonym name
  • related to restin,>100kDa
  • centrosome-associated protein 350
  • Synonym symbol(s) KIAA0480, CAP350, gm133, FLJ44058, FLJ38282
    DNA
    TYPE functioning gene
    STRUCTURE 160.11 kb     38 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13473 - 38 - 3117 - 2006 16314388
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one CAP-Gly domain
    HOMOLOGY
    interspecies homolog to murine Cep350
    intraspecies homolog to restin
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • centrosomal microtubule (MT)-binding protein CAP350 localises at adherens junctions in epithelial cells
  • CEP350 is not only present at the centrosome, but is also present as numerous dots in the pericentrosomal area, and bound preferentially to microtubules in the pericentrosomal area
  • basic FUNCTION
  • anchoring microtubules at the centrosome
  • implicated in the regulation of a class of nuclear hormone receptors in the nucleus
  • CEP350 specifically stabilises Golgi-associated microtubules and in this way participates in the maintenance of a continuous pericentrosomal Golgi ribbon
  • CEP350 may act as an adaptor between adherens junctions and microtubules, thus regulating epithelial differentiation and contributing to the definition of cell architecture
  • role for the CEP19, FGFR1OP and CEP350 module in ciliogenesis and the possible effect of disrupting their functions in ciliopathies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CFAP157 interacts with tubulin and the centrosomal protein CEP350
  • CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS