SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,nucleus,chromatin/chromosome,centromere
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| intracellular,nucleus,nucleolus
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text
| ectopically expressed CENPW primarily accumulated in the nucleolus and remained substantially associated with the nucleolus in stable cells |
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clearly identified in centromere region during mitosis in normal cell |
basic FUNCTION
| tumor-associated gene that is commonly activated in various human cancers and exhibits high transforming activities |
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component of the centromeric complex playing a crucial role in the assembly of functional kinetochore complex during mitosis |
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might be a transcriptional regulator involved in tumorigenesis process |
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is a new component of the centromeric complex that is required for proper chromosome segregation during mitosis |
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plays crucial roles in assembly of the functional kinetochore complex |
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CENPW-CENPT complex functions upstream of other components and that depletion of this complex induced severe defects in the recruitment of other kinetochore components |
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not solely localized in the centromere, but rather widely distributed in various subnuclear compartments, suggesting that it might be involved in a variety of crucial nuclear activities |
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plays an important role in the attachment and interaction between microtubules and kinetochore during mitosis |
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CENPT/CENPW histone fold complex, is an integral part of the inner kinetochore, and is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis |