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FLASH GENE
Symbol CENPW contributors: mct/pgu - updated : 26-07-2015
HGNC name centromere protein W
HGNC id 21488
Location 6q22.32      Physical location : 126.661.252 - 126.669.753
Synonym name
  • cancer-upregulated gene 2
  • chromosome 6 open reading frame 173
  • Synonym symbol(s) CUG2, C6orf173, DKFZp686L1553
    DNA
    TYPE functioning gene
    STRUCTURE 8.50 kb     3 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • TATA-less promoter and a GC-rich putative SP1 and SP3 binding site located at -46 to -36 that was critical in CENPW expression
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 567 - 88 - 2007 17610844
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     salivary gland   highly
    Endocrineparathyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one nuclear localization signal (NLS) sequence of 17 amino acids, starting at amino acid 13
  • secondary structure
  • contain three alpha helices
  • HOMOLOGY
    Homologene
    FAMILY
  • CENPW family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nucleus,nucleolus
    text
  • ectopically expressed CENPW primarily accumulated in the nucleolus and remained substantially associated with the nucleolus in stable cells
  • clearly identified in centromere region during mitosis in normal cell
  • basic FUNCTION
  • tumor-associated gene that is commonly activated in various human cancers and exhibits high transforming activities
  • component of the centromeric complex playing a crucial role in the assembly of functional kinetochore complex during mitosis
  • might be a transcriptional regulator involved in tumorigenesis process
  • is a new component of the centromeric complex that is required for proper chromosome segregation during mitosis
  • plays crucial roles in assembly of the functional kinetochore complex
  • CENPW-CENPT complex functions upstream of other components and that depletion of this complex induced severe defects in the recruitment of other kinetochore components
  • not solely localized in the centromere, but rather widely distributed in various subnuclear compartments, suggesting that it might be involved in a variety of crucial nuclear activities
  • plays an important role in the attachment and interaction between microtubules and kinetochore during mitosis
  • CENPT/CENPW histone fold complex, is an integral part of the inner kinetochore, and is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constitutive centromere-associated network (CCAN) component
  • CENPT/CENPW complex required for mitotic chromosome segregation (directly involved in establishment of centromere chromatin structure coordinately with CENPA)
  • CENP-T-W complex is a dimer of histone-fold domains
  • CENPT-W-APITD1-STRA13 heterotetramer is stably formed using unique tetramerization interfaces on the alpha2 and alpha3 helices of APITD1 and CENPT
  • INTERACTION
    DNA associated with RNA as well as DNA
    RNA associated with RNA as well as DNA
    small molecule
    protein
  • interacting with CENPT (CENPT and CENPW associate with the nucleosomes in centromeric regions and possess direct DNA-binding activities that require their histone-fold domains)
  • specifically interacts with the nucleolar phosphoprotein, nucleophosmin (NPM1)
  • COPS5 directly interacts with both CENPT and CENPW and regulates the stability of the inner kinetochore components CENPT and CENPW
  • HNRNPU interacts with CENPW, and the interaction between HNRNPU and CENPW mutually increased each other's protein stability by inhibiting the proteasome-mediated degradation
  • cell & other
    REGULATION
    induced by by serum stimulation followed by serum deprivation, with SP1 and SP3 transcription factors involved in this transactivation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreas, liver lung, ovary cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • potential to be used as a transcription regulator target in anti-cancer drug development
  • reovirus can be useful in the treatment of transformed cells expressing CUG2
  • ANIMAL & CELL MODELS