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FLASH GENE
Symbol CENPT contributors: mct/pgu - updated : 03-12-2012
HGNC name centromere protein T
HGNC id 25787
Location 16q22.1      Physical location : 67.862.063 - 67.881.361
Synonym symbol(s) C16orf56, CENP-T, FLJ13111, FLJ43376
DNA
TYPE functioning gene
STRUCTURE 19.31 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2360 - 561 - 2006 16716197
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region (189 AA) is required for recruiting the Ndc80 complex and both the CENPT N terminus and the middle region of CENPT (121530) are required for the localization of KNL1 and BUB1, to centromeres
  • secondary structure
  • contain five alpha helices
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • CENPC1 and CENPT are present at the centromere throughout the cell cycle, but the majority of outer kinetochore proteins are recruited only upon entry into mitosis
  • basic FUNCTION
  • part of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation
  • is one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENPT in kinetochore function
  • two constitutive DNA-binding kinetochore components, CENPC1 and CENPT, function to direct kinetochore formation
  • CENPT phosphorylation regulates the mitotic assembly of both endogenous and ectopic kinetochores
  • CENPC1 and CENPT form a critical regulated platform for vertebrate kinetochore assembly
  • in the absence of CENPA, CENPC1 and CENPT are sufficient to direct the assembly of mitotically regulated kinetochore-like structures, and CENPC1 and CENPT can provide a regulated platform for mitotic kinetochore assembly in vertebrate cells
  • CENPA and H3-CENPT/W nucleosome components of the centromere are specialized for centromeric and kinetochore activities, respectively
  • CENPW-CENPT complex functions upstream of other components and that depletion of this complex induced severe defects in the recruitment of other kinetochore components
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU
  • constitutive centromere-associated network (CCAN) component
  • complexing with CENPW (directly involved in establishment of centromere chromatin structure coordinately with CENPA)
  • CENP-T-W complex is a dimer of histone-fold domains
  • CENPT-W-APITD1-STRA13 heterotetramer is stably formed using unique tetramerization interfaces on the alpha2 and alpha3 helices of APITD1 and CENPT
  • N-terminal region of CENP-T (189 aa) is required for recruiting the Ndc80 complex and that both the CENP-T N terminus and the middle region of CENP-T (121530) are required for the localization of KNL1, Bub1, and CPC to centromeres
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CENPT (CENPT and CENPW associate with the nucleosomes in centromeric regions and possess direct DNA-binding activities that require their histone-fold domains)
  • CENPT is a direct centromere receptor of the microtubule-binding NDC80 complex
  • COPS5 directly interacts with both CENPT and CENPW and regulates the stability of the inner kinetochore components CENPT and CENPW
  • the NDC80 complex, which mediates end-on attachment of spindle microtubules, is linked to centromeric chromatin in human cells by two inner kinetochore proteins, CENPT and CENPC1
  • cell & other
    REGULATION
    Other CENPT is degraded when the CENPT-W complex is unable to localize to kinetochores
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS