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FLASH GENE
Symbol CENPM contributors: mct - updated : 28-02-2009
HGNC name centromere protein M
HGNC id 18352
Location 22q13.2      Physical location : 42.334.748 - 42.343.148
Synonym name
  • proliferation associated nuclear element 1
  • chromosome 22 open reading frame 18
  • interphase centromere complex protein 39
  • Synonym symbol(s) MGC861, Pane1, C22orf18, ICEN39, bK250D10.2
    DNA
    TYPE functioning gene
    STRUCTURE 8.40 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D22S1267 - D22S276 - CENPM - D22S1157 - D22S307 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 947 19 180 - Okada (2006)
    5 - 855 - 107 - Okada (2006)
    - - 558 - 58 - Okada (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine 2610019I03Rik
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • encodes a minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL (Brickner 2006)
  • CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling (Foltz 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
  • CENPA nucleosome associated complex (NAC) comprised of three centromere proteins (CENPM, CENPN and CENPT), along with MLF1IP, CENPC and CENPH (Foltz 2006)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS