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FLASH GENE
Symbol CENPI contributors: mct/npt - updated : 27-02-2009
HGNC name centromere protein I
HGNC id 3968
Location Xq22.1      Physical location : 100.354.797 - 100.417.976
Synonym name
  • FSH primary response (LRPR1 homolog, rat) 1
  • interphase centromere complex protein 19
  • leucine-rich primary response protein 1
  • follicle-stimulating hormone primary response protein 1
  • Synonym symbol(s) LRPR1, FSHPRH1, CENP-I, Mis6
    DNA
    TYPE functioning gene
    STRUCTURE 63.18 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - CENPI - DRP2 - BTK - GLA GLA - DXS178 - qter
    Authors Roberts (96)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 2571 86 756 - Okada (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to S.pombe mis6
    ortholog to rattus Fshprh1
    ortholog to murine Fshprh1
    Homologene
    FAMILY
  • mis6 family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • involved in the response of gonadal tissue to FSH
  • constitutive protein of the kinetochore required for the localization of CENPF and the checkpoint proteins MAD1L1 and MAD2L1 to kinetochores (Liu 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text
  • spermatogenesis
  • female gamete generation
  • sex differentiation
  • PATHWAY
    metabolism
    signaling
    a component
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
  • inner kinetochore component (may function, in part, as a marker directing CENPA deposition to centromeres)(Okada 2006)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS