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FLASH GENE
Symbol CENPB contributors: - updated : 22-11-2006
HGNC name centromere protein B, 80kDa
HGNC id 1852
Location 20p13      Physical location : 3.764.499 - 3.767.337
Synonym name
  • centromere autoantigen B
  • centromere protein B (80kD)
  • DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, antisens
    STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    AVP 20p13 arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) UBCE7IP5 20p13 likely ortholog of mouse ubiquitin conjugating enzyme 7 interacting protein 5 FLJ13149 20p13 hypothetical protein FLJ13149 ProSAPiP1 20p13 ProSAPiP1 protein C20orf116 20p13 chromosome 20 open reading frame 116 ITPA 20p inosine triphosphatase (nucleoside triphosphate pyrophosphatase) SLC4A11 20p12 solute carrier family 4, sodium bicarbonate transporter-like, member 11 C20orf194 20p13 chromosome 20 open reading frame 194 UBE2V1P1 20p13 ubiquitin-conjugating enzyme E2 variant 1 pseudogene 1 ATRN 20p13 attractin SF3A3P 20p13 splicing factor 3a, subunit 3 pseudogene GFRA4 20p13-p12 GDNF family receptor alpha 4 ADAM33 20p13 a disintegrin and metalloproteinase domain 33 SN 20p13 sialoadhesin HSPA12B 20p13 heat shock 70kD protein 12B C20orf27 20p13 chromosome 20 open reading frame 27 C20orf28 20pter-q11.23 chromosome 20 open reading frame 28 CENPB 20p13 centromere protein B, 80kDa CDC25B 20p13 cell division cycle 25B C20orf29 20p13 chromosome 20 open reading frame 29 KIAA1271 20p13 KIAA1271 protein PANK2 20p13 pantothenate kinase 2 (Hallervorden-Spatz syndrome) RNF24 20p13-p12.1 ring finger protein 24 LOC388783 20 similar to hypothetical protein RPL21P2 20p13 ribosomal protein L21 pseudogene 2 MGC34919 20p13 hypothetical protein MGC34919 SMOX 20p13 spermine oxidase ADRA1D 20p13 adrenergic, alpha-1D-, receptor
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • sequence homolog to transposases of the pogo superfamily,
  • binding a 18bp sequence (CENP-B box) in alpha-satellite DNA
  • a DNA-binding domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • playing an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes
  • may be a determinant for translational positioning of the centromere-specific nucleosomes through its binding to the nucleosomal CENP-B box
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction between CENP-B and CENP-C may be involved in the correct assembly of CENP-C on alphoid DNA
    cell & other
  • associated with most human centromeres
  • specifically binds to the centromeric 17 base-pair CENP-B box DNA, which contains two CpG dinucleotides
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS