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FLASH GENE
Symbol CELF3 contributors: np/ - updated : 14-01-2008
HGNC name CUGBP, Elav-like family member 3
HGNC id 11967
Location 1q21.3      Physical location : 151.672.535 - 151.689.290
Synonym name
  • trinucleotide repeat containing 4
  • CUG-BP and ETR-3-like factor 3
  • expanded repeat domain, CAG/CTG 4
  • Bruno-like protein 1
  • ELAV-type RNA-binding protein 1
  • CAG repeat protein 4
  • Synonym symbol(s) CAGH4, ERDA4, BRUNOL1, ETR-1, MGC57297, TNRC4
    DNA
    TYPE functioning gene
    STRUCTURE 14.46 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5593 50.5 465 - PMID: 11158314
    - - 5043 - 415 - -
    - - 5352 - 418 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two consecutive N-terminal RNA recognition motifs (RRMs) separated from the C-terminal RRM
  • 15-18-residue polyglutamine sequence
  • HOMOLOGY
    interspecies homolog to Drosophila aret
    homolog to C.elegans C17D12.2
    Homologene
    FAMILY
  • elav family of RNP proteins
  • CELF (CUG-BP- and ETR-3-like factors) family of RNA-binding proteins
  • CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • required for the proper development and maintenance of neurons presumably by affecting RNA metabolism
  • activating tau exon 10 (E10) inclusion
  • brain RNA-binding protein, palying a role in multiple RNA-processing events and having possible implication in the pathogenesis of the tauopathies
  • implicated in two major post-transcriptional regulatory processes, namely the alternative splicing and the control of translation and stability of target mRNAs
  • CELLULAR PROCESS nucleotide, transcription
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS