basic FUNCTION
| playing a role in apoptotic processes |
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required for the proper development and maintenance of neurons presumably by affecting RNA metabolism |
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playing an important role in thymus development |
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implicated in two major post-transcriptional regulatory processes, namely the alternative splicing and the control of translation and stability of target mRNAs |
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RNA-binding protein that regulates mRNA translation and modulates apoptosis |
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having a determinative role for a large subset of splicing transitions that occur during postnatal heart development |
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autoregulatory role as indicated by its direct interaction with functionally significant RNA motifs surrounding the branch sites upstream of exon 6 of the CELF2 transcript itself |
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strongly stimulates CFTR exon 9 skipping, although both proteins bind efficiently to the same RNA motif as TARDBP and with higher affinity |
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both CELF1 and CELF2 regulate several RNA targets in a similar way |
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CELF1 and CELF2 may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos |