basic FUNCTION
| RNA-binding protein that has been implicated in the control of splicing, translation and mRNA degradation |
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playing a critical role in the development of skeletal muscle pathology in patients with Myotonic Dystrophy 1 (DM1) |
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up-regulating p21 during differentiation of skeletal muscle |
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multifunctional, and regulating many posttranscriptional processes including alternative splicing, deadenylation, mRNA decay, and translation |
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implicated in two major post-transcriptional regulatory processes, namely the alternative splicing and the control of translation and stability of target mRNAs |
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involved in the decay of TNF mRNA, and may be an important regulator of decay of a large number of transcripts containing UG-rich elements in their 3'-UTRs |
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mediator of GU-rich element-dependent mRNA decay |
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a multi-faceted factor, involved in a wide range of biological processes including splicing, translation initiation and mRNA degradation |
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with SFRS1, SFRS3, act antagonistically to regulate insulin receptor alternative splicing and the relative ratios of SFRS1, SFRS3 to CUGBP1 in different cells determine the degree of exon inclusion |
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having a determinative role for a large subset of splicing transitions that occur during postnatal heart development |
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role for CELF1 up-regulation in DM1 pathogenesis, and major role in DM1 cardiac pathogenesis |
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RNA binding protein that regulate alternative splicing transitions during development |
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directly controls CD9 expression |
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coordinately regulates the mRNA decay of a network of transcripts involved in cell growth, cell motility, and apoptosis |
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with its target transcripts define a post-transcriptional regulatory network that functions to control cellular growth and homeostasis, and disruptions in this network may play a role in the development of cancer |
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CELF proteins are involved in switching splicing from TPM2 exon 6A towards exon 6B inclusion during myogenic differentiation |
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regulates gene expression at the levels of alternative splicing, mRNA degradation, and translation |
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coordinates networks of transcripts crucial for primary human T cell activation |
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CELF1 and MBNL1 regulate alternative splicing |
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regulates translation of proteins which are critical for maintenance of liver functions |
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possible role of CELF1 in liver dysfunction in patients affected with DM1 |
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it plays a role in post-transcriptional control of albumin expression |
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CELF1 and ELAVL1 jointly regulate the translation of occludin and play a crucial role in the maintenance of tight junction (TJ) integrity in the intestinal epithelial cell monolayer |
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CELF1 and CELF2 may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos |
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is essential for the growth of hepatocellular carcinoma cells |
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CELF1 plays a distinctive and negative role in terminal myocyte differentiation, which partially contribute to DM1 RNA toxicity |
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highly conserved RNA binding protein that regulates pre-mRNA alternative splicing, polyadenylation, mRNA stability, and translation |
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is a key regulator of cardiomyocyte gene expression |
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CELF1 is a critical regulator of insulin secretion via activating PDE3B |
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regulates hepatic stellate cells (HSCs) activation and liver fibrogenesis |
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CELF1 mediates GJA1 mRNA degradation in dilated cardiomyopathy |
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is a multifunctional protein which displays three major functions: regulation of splicing, regulation of translation, and regulation of stability of mRNAs |
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CELF1 and DEK were found to represent early-induced melanoma genes and adverse indicators of overall patient survival |