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FLASH GENE
Symbol CELA3B contributors: npt/ - updated : 16/12/2008
HGNC name chymotrypsin-like elastase family, member 3B
HGNC id 15945
Location 1p36.12      Physical location : 22.303.417 - 22.315.845
Synonym name
  • protease E
  • elastase 3B, pancreatic
  • proteinase E
  • cholesterol-binding pancreatic protease
  • pancreatic endopeptidase E
  • Synonym symbol(s) ELA3B, CBPP
    EC.number 3.4.21.70
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 12.43 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1055 29 270 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide and propeptide of 28AA
  • isoforms Precursor propeptide of 270AA and 29.3kda
    HOMOLOGY
    interspecies homolog to murine Ela1,Ela2,Ela3b
    homolog to rattus Ela1,Ela2
    intraspecies paralog to ELA3A
    Homologene
    FAMILY
  • peptidase family S1/trypsin family
  • elastase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • preferentially cleaves proteins after alanine residues
  • may also function in the intestinal transport and metabolism of cholesterol
  • may possess not only a digestive function but also function(s) related to cholesterol metabolism or transport in the intestine
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS