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FLASH GENE
Symbol CELA3A contributors: np/ - updated : 16/12/2008
HGNC name chymotrypsin-like elastase family, member 3A
HGNC id 15944
Location 1p36.12      Physical location : 22.328.148 - 22.339.033
Synonym name
  • elastase 3A, pancreatic
  • elastase 3A, pancreatic (protease E)
  • protease E
  • protease E
  • Synonym symbol(s) ELA3, ELA3A
    EC.number 3.4.21.70
    DNA
    TYPE functioning gene
    STRUCTURE 10.89 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 922 29 270 - Shimada (2002)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide and propeptide of 28AA
  • 1 peptidase S1 domain
  • isoforms Precursor propeptide of 270AA and 29.5kDa
    HOMOLOGY
    intraspecies homolog to elastases I,elastases II
    paralog to ELA3B
    Homologene
    FAMILY
  • peptidase S1 family
  • elastase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • serine proteases that hydrolyze many proteins
  • preferentially cleaves proteins after alanine residues
  • may possess not only a digestive function but also function(s) related to cholesterol metabolism or transport in the intestine
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in pancreatic carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS