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FLASH GENE
Symbol CEBPG contributors: mct/npt - updated : 23-03-2010
HGNC name CCAAT/enhancer binding protein (C/EBP), gamma
HGNC id 1837
Location 19q13.11      Physical location : 33.864.608 - 33.873.591
Synonym name C/EBP gamma
Synonym symbol(s) GPE1BP, IG/EBP-1
DNA
TYPE functioning gene
STRUCTURE 8.98 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3750 - 150 - Hattori (2003)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon moderately
 pancreas exocrine   moderately
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a basic region involved in DNA binding
  • a leucine zipper motif involved in dimerization
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Cebpg
    ortholog to murine Cebpg
    Homologene
    FAMILY
  • bZIP family
  • C/EBP subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • activator of transcription
  • might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites
  • transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals (Mullins 2005)
  • regulates ERCC5 expression and this regulation is modified by E2F1/YY1 interactions (Crawford 2007)
  • important regulator of cytokine expression in human neutrophils (Cloutier 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer
  • can form stable heterodimers with C/EBP alpha and beta and with Fos protein
  • INTERACTION
    DNA binding to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bronchogenic carcinoma
    Variant & Polymorphism other several polymorphisms contributing to risk for bronchogenic carcinoma (Crawford 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS