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FLASH GENE

Symbol

CEACAM8

contributors: mct - updated : 03-05-2011

HGNC name	carcinoembryonic antigen-related cell adhesion molecule 8
HGNC id	1820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.2      Physical location : 43.084.394 - 43.099.082
Synonym name	carcinoembryonic antigen gene family, 6
Synonym symbol(s)	CGM6, CD67, CD66b, NCA-95

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	14.69 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see CEA@ ,PSG@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001816 6 - 2333 - 349 - 2007 18056392

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic eosinophil Homo sapiens

cell lineage
cell lines	leukocytes of chronic myeloid leukemia
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an immunoglobulin-like V-type domain
	two immunoglobulin-like C2-type domains

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to carcinoembryonic antigen

Homologene

FAMILY	immunoglobulin superfamily
	CEA subfamily

CATEGORY

adhesion , antigen

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	attached to the membrane by a GPI-anchor
	localized in lipid rafts

basic FUNCTION	acting as a tumor antigen
	involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary myelofibrosis (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS