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FLASH GENE
Symbol CEACAM7 contributors: mct - updated : 23-09-2020
HGNC name carcinoembryonic antigen-related cell adhesion molecule 7
HGNC id 1819
Location 19q13.2      Physical location : 42.177.234 - 42.192.096
Synonym name carcinoembryonic antigen gene family,2
Synonym symbol(s) CGM2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 14.97 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see CEA@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 splicing 2396 29.4 265 - 2015 26323304
5 splicing 2376 29.4 265 - 2015 26323304
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
 intestinelarge intestinerectum   Homo sapiens
Endocrinepancreas   moderately Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
Epithelialsecretoryglandularendocrine  Homo sapiens
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal dimerization domain
  • an immunoglobulin-like V-type domain
  • an immunoglobulin-like C2-type domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
  • CATEGORY adhesion , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon
  • cellular adhesion protein that is expressed on the surface of colon and rectum epithelial cells and is downregulated in colorectal cancers
  • achieves cell adhesion through dimerization of the N-terminal IgV domain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFNG has two important effects on the expression levels of the CEA family molecules in colon epithelial cells: direct upregulation of CEACAM1 and promotion of cell differentiation resulting in increased expression of CEA and CEACAM6 and decreased expression of CEACAM7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with unfavorable prognosis in Colorectal cancer
    tumoral     --low  
    relatively decreased in rctal tumors that developed recurrence compared with nonrecurrence, significantly for stage II patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of Colorectal cancer
  • potential tumor marker to define a subset of patients who benefit most from adjuvant therapy
  • Therapy target
    ANIMAL & CELL MODELS