Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CEACAM6 contributors: mct - updated : 03-05-2011
HGNC name carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
HGNC id 1818
Location 19q13.2      Physical location : 42.259.397 - 42.276.113
Synonym name
  • formerly nonspecific cross-reacting antigen
  • normal cross-reacting antigen
  • CD66c antigen
  • Synonym symbol(s) NCA, CEAL, CD66c
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.72 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see CEA@
    Physical map
    MGC20255 19q13.31 hypothetical protein MGC20255 TGFB1 19q13.2 transforming growth factor, beta 1 (Camurati-Engelmann disease) MGC4093 19q13.31 hypothetical protein MGC4093 RRP46 19q13.1 exosome component Rrp46 BCKDHA 19q13.2 branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease) BGALT15 19q13.31 beta galactosyltransferase BGALT15 FLJ10241 19q13.31 hypothetical protein FLJ10241 LOC388543 19 LOC388543 LOC283855 19q13.31 similar to tropomyosin 3 PLEKHA3P1 19 pleckstrin homology domain-containing, family A member 3 pseudogene 1 R29124_1 19q13.31 hypothetical protein R29124_1 CEACAMP3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 3 CEACAM4 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 4 CEACAM7 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 7 CEACAM5 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM6 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) CEACAM3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 3 LOC388544 19 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) MGC42718 19q13.31 hypothetical protein MGC42718 DMRTC2 19q13.31 DMRT-like family C2 RPS19 19q13.2 ribosomal protein S19 CD79A 19q13.2-q13.3 CD79A antigen (immunoglobulin-associated alpha) ARHGEF1 19q13,13 Rho guanine nucleotide exchange factor (GEF) 1 LOC390937 19 similar to Erf RABAC1 19q13.13-q13.2 Rab acceptor 1 (prenylated) ATP1A3 19q13.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide GRIK5 19q13.2 glutamate receptor, ionotropic, kainate 5 FLJ22059 19q13.31 hypothetical protein FLJ22059 POU2F2 19q13.31 POU domain, class 2, transcription factor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2631 - 344 - 2009 19411761
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue  highly
     stomach   highly
    Endocrinepancreas   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like V-type domain
  • two immunoglobulin-like C2-type domains
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
  • CATEGORY adhesion , antigen , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • modulating pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner
  • intercellular adhesion molecule overexpressed in a wide variety of cancers, including colon, breast and lung and associated with tumourigenesis, tumour cell adhesion, invasion and metastasis (
  • unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells (
  • cellular protein that restricts the ability of adenoviral vectors to infect cancer cells
  • can antagonize the Src signaling pathway
  • implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of primary myelofibrosis (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic adenocarcinoma
    tumoral     --over  
    in primary myelofibrosis (
    tumoral     --over  
    in borderline and invasive mucinous ovarian cancers (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential prognostic indicator and potential chemoresistant marker to gemcitabine for patients with intrahepatic cholangiocarcinoma
  • could be an important biomarker of metastasis(
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for the development of biomarkers to predict the response of patients to adenovirus-based therapies, as well as for the development of more potent adenovirus-based therapeutics in cancer
    ANIMAL & CELL MODELS