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FLASH GENE

Symbol

CEACAM3

contributors: mct - updated : 13-12-2016

HGNC name	carcinoembryonic antigen-related cell adhesion molecule 3
HGNC id	1815

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.2      Physical location : 42.300.533 - 42.315.591
Synonym name	antigen gene family,1
	carcinoembryonic antigen CGM1
	nonspecific cross-reacting antigen
	carcinoembryonic antigen gene family member 1
Synonym symbol(s)	CGM1, CD66D, CEA, MGC119875, W282

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	15.06 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see CEA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001815 7 splicing 1151 NP_001806 27.1 252 - Kuroki, Nagel (1993) also called CGM1a variant 2 - splicing 1640 isoform 2 19.4 177 - Kuroki, Nagel (1993) also called CGM1b variant 3 - splicing - isoform 3 22.8 212 - Kuroki, Nagel (1993) also called CGM1c

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system placenta

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an immunoglobulin-like V-type domain
	a cytosolic domain involved in S100A9 interaction

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to carcinoembryonic antigen

Homologene

FAMILY	immunoglobulin superfamily
	CEA subfamily

CATEGORY

adhesion , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	acting as a tumor antigen
	playing an important role in the clearance of pathogens by the innate immune system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

GRB14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS