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FLASH GENE
Symbol CEACAM16 contributors: mct - updated : 22-09-2017
HGNC name carcinoembryonic antigen-related cell adhesion molecule 16
HGNC id 31948
Corresponding disease
DFNA4B Deafness, autosomal dominant 4B
Location 19q13.31      Physical location : 45.202.420 - 45.213.984
Synonym name carcinoembryonic antigen like-2 protein
Synonym symbol(s) CEAL2, DFNA4B
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 11.56 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1797 - 484 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/EquilibriumearinnercochleaCortispecific Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumhair cell receptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • immunoglobulin superfamily
  • CEA family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • can probably form higher order structures with other tectorial membrane proteins such as TECTA and TECTB and influences the physical properties of the tectorial membrane
  • evolution of CEACAM16 might have been an important step for the specialization of the mammalian cochlea, allowing hearing over an extended frequency range
  • TECTA, TECTB, and CEACAM16 are secreted glycoproteins that are present in the tectorial membrane (TM), an extracellular structure overlying the hearing organ of the inner ear, the organ of Corti
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is an TECTA-interacting protein that concentrates at the point of attachment of the tectorial membrane (TM) to the stereocilia
  • CEACAM16 interact with TECTA and TECTB, indicating that it may stabilize interactions between TECTA and TECTB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA4B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS