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FLASH GENE
Symbol CDY1 contributors: - updated : 22-12-2004
HGNC name chromodomain protein, Y chromosome, 1
HGNC id 1809
Location Yq11.21      Physical location : 26.191.378 - 27.771.046
Synonym name testis-specific chromodomain protein on Y
Synonym symbol(s) CDY, CDY1A
EC.number 2.3.1.48
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)    multiple  Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located in a AZF deleted region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2236 60.5 540 - Lahn
a single exon transcript resulting in a protein (a) shortened at the C-terminus compared to isoform b
- splicing 2373 - 554 - Lahn
using a splice site located within,and near the 3' end of,the single exon of the major variant (1)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage late spermatids
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chromodomain, a histone acetyltransferase catalytic domain
  • a SNF2 related helicase (ATPase) domain
  • HOMOLOGY
    intraspecies paralog to CDY2
    Homologene
    FAMILY CHD family
    CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized to the nucleus of late spermatids where histone hyperacetylation takes place
    basic FUNCTION
  • involved in compaction during spermatogenesis, in late stage
  • acting as gene repressors
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component components of heterochromatin-like complexes
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS