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FLASH GENE
Symbol CDY1 contributors: - updated : 22-12-2004
HGNC name chromodomain protein, Y chromosome, 1
HGNC id 1809
Location Yq11.21      Physical location : 26.191.378 - 27.771.046
Synonym name testis-specific chromodomain protein on Y
Synonym symbol(s) CDY, CDY1A
EC.number 2.3.1.48
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)    multiple  Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF381P Y zinc finger protein 381, Y-linked pseudogene DAZ4 Yq11.23 deleted in azoospermia 4 DAZ Yq11.23 deleted in azoospermia DAZ2 Yq11.23 deleted in azoospermia 2 DAZ3 Yq11.23 deleted in azoospermia 3 LOC360020 Yq11.223 protein phosphatase 1, regulatory (inhibitor) subunit 12B pseudogene RBMY2CP Yq11.223 RNA binding motif protein, Y-linked, family 2, member C pseudogene LOC379030 LOC386695 Yq11.223 oral-facial-digital syndrome 1 pseudogene CDY22P Yq11.223 chromodomain protein, Y-linked 22 pseudogene CDY21P Yq11.223 chromodomain protein, Y-linked 21 pseudogene LOC379032 TTTY3 Y testis-specific transcript, Y-linked 3 LOC386696 Yq11.223 oral-facial-digital syndrome 1 pseudogene CDY1 Yq11.21 chromodomain protein, Y chromosome, 1 CDY17P Yq11.223 chromodomain protein, Y-linked 17 pseudogene LOC360024 Yq11.223 intersectin 2 pseudogene LOC84664 Yq11.223 melanoma-associated chondroitin sulfate proteoglycan-like LOC359998 Yq11.2 CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion pseudogene GOLGA2LY Yq11.22 golgi autoantigen, golgin subfamily a, 2-like, Y-linked LOC360025 Yq11.223 intersectin 2 pseudogene LOC360016 Yq11.223 capicua homolog (Drosophila) pseudogene LOC389925 Y similar to bA476I15.3 (novel protein similar to septin) LOC286570 Yq11.223 ribosomal protein L41 pseudogene LOC379012 Yq11.223 RNA binding motif protein, Y-linked, family 2, pseudogene TTTY4 Yq11.22 testis-specific transcript, Y-linked 4 LOC392603 Y similar to zinc finger protein 92 (HTF12) LOC389926 Y similar to deleted in azoospermia LOC392604 Y similar to zinc finger protein 92 (HTF12) LOC392605 Y similar to hypothetical protein MGC42493
regionally located in a AZF deleted region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2236 60.5 540 - Lahn
a single exon transcript resulting in a protein (a) shortened at the C-terminus compared to isoform b
- splicing 2373 - 554 - Lahn
using a splice site located within,and near the 3' end of,the single exon of the major variant (1)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage late spermatids
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chromodomain, a histone acetyltransferase catalytic domain
  • a SNF2 related helicase (ATPase) domain
  • HOMOLOGY
    intraspecies paralog to CDY2
    Homologene
    FAMILY CHD family
    CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized to the nucleus of late spermatids where histone hyperacetylation takes place
    basic FUNCTION
  • involved in compaction during spermatogenesis, in late stage
  • acting as gene repressors
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component components of heterochromatin-like complexes
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS