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FLASH GENE
Symbol CDX1 contributors: mct/pgu - updated : 05-12-2019
HGNC name caudal type homeobox transcription factor 1
HGNC id 1805
Location 5q32      Physical location : 149.546.343 - 149.564.120
Synonym symbol(s) MGC116915
DNA
TYPE functioning gene
STRUCTURE 17.78 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure a typical CpG island with a CpG observed/expected ratio of 0.80, suggesting that it is a target of aberrant methylation
MAPPING cloned Y linked   status confirmed
Map cen - PDE6A - CSF1R - PDGFRB - CDX1 - RPS14 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1772 - 265 - 2018 29550489
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an helix-turn-helix homeobox DNA binding domain
HOMOLOGY
interspecies homolog to rattus Cdx1 (83.5 pc)
homolog to murine Cdx1 (85.3 pc)
Homologene
FAMILY caudal homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • acting as a transcriptional regulator of insulin gene
  • inhibiting proliferation of intestinal epithelial cells
  • regulating intestine-specific genes involved in differentiation
  • involved in the regulation of specific intestinal promoters, including intestinal ALP, sucrase-isomaltase, intestinal phospholipase A/lysophospholipase (IPAL)
  • may be an important factor in the process toward malignant transformation during the first steps of tumorigenesis
  • could play a role in the terminal differentiation of the intestine
  • inducing expression of the intestinal alkaline phosphatase gene
  • inhibiting beta-catenin/T-cell factor transcriptional activity
  • dispensable for intestinal development and that its overexpression could increase malignancy in early stages of tumourigenesis
  • enhanced the expression of PPARA gene, a master transcriptional regulator of intestinal differentiation(Park 2009)
  • with CDX2, regulate gut development and differentiation of intestinal epithelial cells
  • CDX1 and CDX2 binds to the SLC5A8 promoter, might therefore regulate the uptake of these substances in the colon
  • homeodomain transcription factor with well-established roles in anteroposterior patterning
  • pivotal role for Cdx1 function upstream of PTK7 and neural tube closure in vertebrates
  • both CDX1 and CDX2 contribute to homeostasis of the colon
  • CDX1 and CDX2 exhibit transcriptional specificity in the intestine
  • oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells
  • role of CDX1 during epicardial development, suggesting that transient expression of CDX1 promotes epicardial epithelial-to-mesenchymal transition (EMT)
  • CDX1/CDX2, and KLF5 are key transcription factors involved in SHH pathway and cancer stem cells
  • CDX1 contributes to the tumorigenesis and progression of gastric cancer
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • organ morphogenesis
  • enterocyte differentiation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with the TATA-box binding protein (TBP) on the promoter of the glucose-6-phosphatase (G6Pase) gene, via its homeodomain
  • interacting with CEBPA (capable of enhancing CDX1-mediated transactivation of the PPARG via direct protein interaction depending on the combination of a variety of cellular signals)
  • CDX transcription factors bind to the promoter region of SLC5A8 and transactivate SLC5A8 reporter constructs
  • interacting with MAFB (one of the earliest direct targets of CDX1 that plays a direct role in early hindbrain patterning
  • cell & other
    REGULATION
    inhibited by CDX2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal carcinoma by promoter methylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    potential of targeting CDX1 to treat gastric cancer
    ANIMAL & CELL MODELS