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FLASH GENE
Symbol CDX1 contributors: mct/pgu - updated : 11-07-2011
HGNC name caudal type homeobox transcription factor 1
HGNC id 1805
Location 5q33.1      Physical location : 149.546.343 - 149.564.120
DNA
TYPE functioning gene
STRUCTURE 17.78 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure a typical CpG island with a CpG observed/expected ratio of 0.80, suggesting that it is a target of aberrant methylation
MAPPING cloned Y linked   status confirmed
Map cen - PDE6A - CSF1R - PDGFRB - CDX1 - RPS14 - qter
Physical map
ADRB2 5q31.3 adrenergic, beta-2-, receptor, surface KIAA1985 LOC255187 5q33.1 hypothetical LOC255187 KIAA0843 FLJ36748 5q33.1 hypothetical protein FLJ36748 GRPEL2 5q33.1 GrpE-like 2, mitochondrial (E. coli) MGC3265 5q33.1 hypothetical protein MGC3265 IL17B 5q32-34 interleukin 17B CSNK1A1 13q13 casein kinase 1, alpha 1 LOC389337 5 similar to hypothetical protein 4933429F08 PERC 5q33.1 similar to hypothetical protein 4933429F08 PDE6A 5q31.3 phosphodiesterase 6A, cGMP-specific, rod, alpha SLC26A2 5q31.3 solute carrier family 26 (sulfate transporter), member 2 TIGD6 5q32 tigger transposable element derived 6 RPS20P4 5q33-qter ribosomal protein S20 pseudogene 4 CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog RPL7P 5q33.3 ribosomal protein L7 pseudogene PDGFRB 5q31.3 platelet-derived growth factor receptor, beta polypeptide CDX1 5q31.3 caudal type homeo box transcription factor 1 SLC6A7 5q31-q32 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha LOC340075 5q33.1 similar to RIKEN cDNA 9330196J05 TCOF1 5q32-q33.1 Treacher Collins-Franceschetti syndrome 1 CD74 5q31.3 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) RPS14 5q32 ribosomal protein S14 NDST1 5q31.3-q32 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 SYNPO 5q33.1 synaptopodin MYOZ3 5q33.1 myozenin 3 FLJ10290 5q33.1 hypothetical protein FLJ10290 DCTN4 5q31-q32 dynactin 4 (p62) NID67 5q33.1 putative small membrane protein NID67 LRG47 5q33.1 LRG-47-like protein ZNF300 21 zinc finger protein 300 GPX3 5q23 glutathione peroxidase 3 (plasma) TNIP1 5q32-q33.1 TNFAIP3 interacting protein 1 ANXA6 5q32 annexin A6 DKFZP434C171 5q33.1 DKFZP434C171 protein GM2A 5q32 GM2 ganglioside activator protein SLC36A3 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 3 SLC36A2 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 2 LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1772 - 265 - 1997 9036867
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an helix-turn-helix homeobox DNA binding domain
HOMOLOGY
interspecies homolog to rattus Cdx1 (83.5 pc)
homolog to murine Cdx1 (85.3 pc)
Homologene
FAMILY caudal homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • acting as a transcriptional regulator of insulin gene
  • inhibiting proliferation of intestinal epithelial cells
  • regulating intestine-specific genes involved in differentiation
  • involved in the regulation of specific intestinal promoters, including intestinal ALP, sucrase-isomaltase, intestinal phospholipase A/lysophospholipase (IPAL)
  • may be an important factor in the process toward malignant transformation during the first steps of tumorigenesis
  • could play a role in the terminal differentiation of the intestine
  • inducing expression of the intestinal alkaline phosphatase gene
  • inhibiting beta-catenin/T-cell factor transcriptional activity
  • dispensable for intestinal development and that its overexpression could increase malignancy in early stages of tumourigenesis
  • enhanced the expression of PPARA gene, a master transcriptional regulator of intestinal differentiation(Park 2009)
  • with CDX2, regulate gut development and differentiation of intestinal epithelial cells
  • CDX1 and CDX2 binds to the SLC5A8 promoter, might therefore regulate the uptake of these substances in the colon
  • homeodomain transcription factor with well-established roles in anteroposterior patterning
  • pivotal role for Cdx1 function upstream of PTK7 and neural tube closure in vertebrates
  • both CDX1 and CDX2 contribute to homeostasis of the colon
  • CDX1 and CDX2 exhibit transcriptional specificity in the intestine
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • organ morphogenesis
  • enterocyte differentiation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with the TATA-box binding protein (TBP) on the promoter of the glucose-6-phosphatase (G6Pase) gene, via its homeodomain
  • interacting with CEBPA (capable of enhancing CDX1-mediated transactivation of the PPARG via direct protein interaction depending on the combination of a variety of cellular signals)
  • CDX transcription factors bind to the promoter region of SLC5A8 and transactivate SLC5A8 reporter constructs
  • interacting with MAFB (one of the earliest direct targets of CDX1 that plays a direct role in early hindbrain patterning
  • cell & other
    REGULATION
    inhibited by CDX2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal carcinoma by promoter methylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS