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FLASH GENE
Symbol CDS2 contributors: npt/mct - updated : 28/10/2008
HGNC name CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
HGNC id 1801
Location 20p13      Physical location : 5.107.481 - 5.171.987
Synonym name
  • CTP:phosphatidate cytidylyltransferase 2
  • CDP-DAG synthase 2
  • Synonym symbol(s) FLJ38111, RP4-680N4.2
    EC.number 2.7.7.41
    DNA
    TYPE like-sequence
    STRUCTURE 64.50 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1271 20p13 KIAA1271 protein PANK2 20p13 pantothenate kinase 2 (Hallervorden-Spatz syndrome) RNF24 20p13-p12.1 ring finger protein 24 LOC388783 20 similar to hypothetical protein RPL21P2 20p13 ribosomal protein L21 pseudogene 2 MGC34919 20p13 hypothetical protein MGC34919 SMOX 20p13 spermine oxidase ADRA1D 20p13 adrenergic, alpha-1D-, receptor RPL7AL2 20p13 ribosomal protein L7a like 2 RPS4L2 20p13 ribosomal protein S4-like 2 PRNP 20p12.3 prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) PRND 20pter-p12 prion protein 2 (dublet) LOC149830 20p13 M8 protein RASSF2 20pter-p12.1 Ras association (RalGDS/AF-6) domain family 2 SLC23A2 5q31.2-q31.3 solute carrier family 23 (nucleobase transporters), member 2 C20orf30 20p13 chromosome 20 open reading frame 30 PCNA 20p12.3 proliferating cell nuclear antigen CDS2 20p13 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 LOC388784 20 similar to dJ680N4.2 (ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)) GPR73L1 20p13 G protein-coupled receptor 73-like 1 LOC388785 20 hypothetical gene supported by AK090863 MGC35023 20p13 hypothetical protein MGC35023 LOC388786 20 LOC388786 LOC388787 20 LOC388787 RPS18P1 20p13 ribosomal protein S18 pseudogene 1 KIAA1434 20p13 hypothetical protein KIAA1434 EIF4EL2 20p13 eukaryotic translation initiation factor 4E-like 2 FLJ25067 20p13 hypothetical protein FLJ25067 CHGB 20p12.3 chromogranin B (secretogranin 1) LOC391230 20 similar to ankyrin repeat domain protein 15; kidney ankyrin repeat-containing protein CGI-09 20p13 CGI-09 protein MCM8 20p12.3 MCM8 minichromosome maintenance deficient 8 (S. cerevisiae) C20orf155 20p13-p12.3 chromosome 20 open reading frame 155 C20orf75 20p13 chromosome 20 open reading frame 75 C20orf42 20p12.3 chromosome 20 open reading frame 42 LOC219414 20p12.3 similar to TAR DNA binding protein LOC149844 20p12.3 NS1-associated protein 1 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 9500 - - - Volta, 99
    - - - 4400 - - - Volta, 99
    13 - 2711 - 445 - Olsen (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver    
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
    Nervousnerve   highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage in the differentiating neuroblasts of the neural retina
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text highly expressed in the differentiating neuroblasts of the neural retina and in the central nervous system during embryonic development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine transmembrane domains
  • HOMOLOGY
    interspecies homolog to Drosophila cds
    homolog to murine Cds2
    homolog to C.elegans c33h5.18
    homolog to Drosophila cdp
    intraspecies homolog to CDS1
    Homologene
    FAMILY
  • CDS family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text matrix side of the inner mitochondrial membrane
    basic FUNCTION
  • converting phosphatidic acid in CDP (cytidine diphosphate) DAG (dicylglycerol) regulator of cellular phosphatidylinositol content
  • be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis
  • required for phototransduction
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
  • involved in phosphoinositide mediated signaling pathway, phospholipid biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS