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FLASH GENE
Symbol CDR2 contributors: - updated : 14-12-2005
HGNC name cerebellar degeneration-related protein 2, 62kDa
HGNC id 1799
Location 16p12.2      Physical location : 22.357.258 - 22.385.938
Synonym name paraneoplastic cerebellar degeneration-associated antigen
Synonym symbol(s) CDR62, Yo
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC57149 16p11.2 hypothetical protein A-211C6.1 FLJ23558 16p13.11-p12.3 hypothetical protein FLJ23558 DNAH3 16p12 dynein, axonemal, heavy polypeptide 3 LOC57146 16p12 promethin ZP2 16p12.2 zona pellucida glycoprotein 2 (sperm receptor) FLJ38819 16p12.3 hypothetical protein FLJ38819 CRYM 16p13.11-p12.3 crystallin, mu LOC388220 16 LOC388220 LOC92267 16p12.3 similar to FLJ12363 protein LOC388221 16 similar to nuclear pore complex interacting protein LOC388222 16 similar to MGC9515 protein LOC388223 16 similar to KIAA0220 IMAA 16p12 hLAT1-3TM LOC388224 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase DREV1 16p13-p12 DORA reverse strand protein 1 IGSF6 16p13-p12 immunoglobulin superfamily, member 6 OTOA 16p12.12 otoancorin LOC94431 16p12.3 similar to RNA polymerase I transcription factor RRN3 LOC390681 16 similar to RNA polymerase I transcription factor RRN3 MGC9515 16p12.3 hypothetical protein MGC9515 LOC390682 16 similar to PI-3-kinase-related kinase SMG-1 isoform 1; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase LOC342293 16p12.3 similar to hypothetical protein UQCRC2 16p12.2 ubiquinol-cytochrome c reductase core protein II MGC50721 16p12.3 hypothetical protein MGC50721 LOC146174 16p12.3 hypothetical protein LOC146174 LOC146177 16p12.3 hypothetical protein LOC146177 LOC390683 16 similar to NAD(P) dependent steroid dehydrogenase-like EEF2K 16p12.1-q12.2 similar to NAD(P) dependent steroid dehydrogenase-like RPC5 16p12.3 RNA polymerase III 80 kDa subunit RPC5 CDR2 16p12.2 cerebellar degeneration-related protein 2, 62kDa LOC390684 16 similar to RRN3 LOC283846 16p12.3 PI-3-kinase-related kinase SMG-1-like LOC388225 16 similar to MGC9515 protein HS3ST2 16p12 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 KIAA1203 16p12.3 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 SCNN1G 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, gamma SCNN1B 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) COG7 16p11.2 component of oligomeric golgi complex 7 GGA2 16p12 golgi associated, gamma adaptin ear containing, ARF binding protein 2 UBPH 16p12 similar to ubiquitin binding protein NDUFAB1 16p12.3-p12.1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa FLJ21816 16p12.3 hypothetical protein FLJ21816 MGC3248 16p12.3 dynactin 4 PLK LOC388226 16 similar to protein kinase/ribonuclease IRE1 beta ERN2 16p12.2 ER to nucleus signalling 2 LOC63928 16p12.3 hepatocellular carcinoma antigen gene 520
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum  
Reproductivemale systemprostate   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION putative neuronal signal transduction protein
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
inhibition of function by autoantibodies in paraneoplastic cerebellar degeneration may contribute to Purkinje neuronal death in breast and ovarian cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS