basic FUNCTION
| involved in myogenic differentiation |
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functions to activate myogenic bHLH factors via enhanced heterodimer formation, most likely by inducing hyperphosphorylation of E proteins |
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CDON and BOC encode cell surface Ig/fibronectin superfamily members linked to muscle differentiation |
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CDON and APPL1 are required for efficient AKT1 activation during myoblast differentiation |
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activates AKT1 through association with APPL1 during myoblast differentiation, and this complex likely mediates some of the promyogenic effect of cell-cell interaction |
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CDON and BOC have specific, selective roles in Shh signaling |
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GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube |
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GAS1 and CDON are coexpressed in muscle cells and form a complex in differentiating myoblasts |
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CDON functions as a component of multiprotein cell surface complexes to promote myogenesis |
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promyogenic CDON signaling is critical for KCNJ2 activities in the induction of myogenic differentiation |
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CDON, is likely important in initiating oligodendrocytes (OLGs) differentiation and axon myelination by promoting the formation of branched cellular processes |