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FLASH GENE
Symbol CDKN2D contributors: - updated : 20-05-2006
HGNC name cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
HGNC id 1790
Location 19p13.2      Physical location : 10.677.138 - 10.679.655
Synonym name inhibitor of cyclin-dependent kinase 4d
Synonym symbol(s) p19, INK4D, p19-INK4D
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure several Sp1 and activating protein 2 binding sites involved in the transcription
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
text two alternative transcripts encoding the same product
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connective    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
cell cycle     cell cycle, S
Text liver, brain, testis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four tandemly arranged ankyrin motifs
HOMOLOGY
Homologene
FAMILY CDKN2 cyclin-dependent kinase inhibitor family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • regulator of the cell cycle
  • function as a cell growth regulator that controls cell cycle G1 progression
  • CELLULAR PROCESS cell cycle, checkpoint
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • passage through the G1 checkpoint
  • playing a role in spermatogenesis
  • repressing neural proliferation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative regulator of cyclin dependent 4 and 6 (CDK4/CDK6)
  • inhibitor of RB1 phosphorylation by CDK4/CDK6
  • inhibitor of phosphorylation of RB by CDK4 and CDK6
  • cell & other
    REGULATION
    Other negative regulator of the protooncogene cyclin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS