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FLASH GENE
Symbol CDKN2C contributors: mct/npt - updated : 15-06-2009
HGNC name cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
HGNC id 1789
Location 1p32.3      Physical location : 51.434.366 - 51.440.307
Synonym name
  • cyclin dependent kinase 6 (CDK6)
  • cyclin-dependent kinase 6 inhibitor p18
  • Synonym symbol(s) P18, INK4C, CDKN6, p18-INK4C, p18-INK6
    DNA
    TYPE functioning gene
    STRUCTURE 5.94 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ11588 1p33 hypothetical protein FLJ11588 ELAVL4 1p34 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) LOC343184 1p33 similar to ribosomal protein S2 LOC391038 1 similar to Protein C14orf111 (CGI-35) DMRTA2 1p33 DMRT-like family A2 FAF1 1p33 Fas (TNFRSF6) associated factor 1 MRPS6P2 1p33 mitochondrial ribosomal protein S6 pseudogene 2 LOC51336 1p32.3 mesenchymal stem cell protein DSCD28 CDKN2C 1p32 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) LOC284546 1p32.3 similar to RIKEN cDNA 4930522H14 LOC391039 1 similar to Cofilin, non-muscle isoform (18 kDa phosphoprotein) (P18) RNF11 1p32-p31 ring finger protein 11 LOC388631 1 similar to ribosomal protein S2; 40S ribosomal protein S2 C1orf34 1p33 chromosome 1 open reading frame 34 EPS15 1p32.2-p31 epidermal growth factor receptor pathway substrate 15 OSBPL9 1p34.2-p32.2 oxysterol binding protein-like 9 NRD1 1p32.2 nardilysin (N-arginine dibasic convertase) RAB3B 1p32-p31 RAB3B, member RAS oncogene family TLP19 1p32.3 endoplasmic reticulum thioredoxin superfamily member, 18 kDa LOC112970 1p32.3 hypothetical protein BC012173 LOC391040 1 similar to RIKEN cDNA 5730434I03 gene MADHIP 1p32.3 MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor KIAA1836 1p32.3 KIAA1836 protein ORC1L 1p32 origin recognition complex, subunit 1-like (yeast) FLJ14936 1p33-p32.1 hypothetical protein FLJ14936 KIAA0191 1p31-32 hypothetical protein FLJ14936 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
    RNA
    TRANSCRIPTS type messenger
    text two alternative transcripts giving the same product
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2104 18 168 - Uziel (2005)
    2 - 1273 18 168 - Uziel (2005)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrineadrenal gland   highly
     pancreas    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, G1
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four tandemly arranged ankyrin motifs involved in the ability of P18 to bind and inhibit CDK4 and CDK6
  • HOMOLOGY
    Homologene
    FAMILY
  • CDKN2 cyclin-dependent kinase inhibitor family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibiting cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB
  • tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development (van Veelen 2009)
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    text inhibiting phosphorylation of RB passage through the G1 checkpoint
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of p18 with CDK6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK6
  • CDK4
  • association between NR4A2 overexpression and upregulation of CDKN2C, suggesting a mechanism by which NR4A2 could regulate haematopoietic stem cells quiescence
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    by hypermethylation in Hodgkin lymphoma (contributing to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed- Sternberg cells)
    tumoral       loss of function
    in medulloblastoma
    tumoral   LOH    
    in pituitary adenoma (Kirsch 2009)
    tumoral somatic mutation      
    in medullary thyroid carcinoma and pheochromocytoma (van Veelen 2009)
    tumoral   deletion    
    in multiple myeloma, implicated in in the progression and clinical outcome of myeloma (Leone 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS