SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| text
| CDKL5 phosphorylation is required for its entrance into the nucleus whereas a portion of the C-terminal domain is responsible for a stable residency in this cellular compartment probably through protein-protein interactions |
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shuttles between the two main cellular compartments and the relative concentrations in each compartment seem to vary in different brain areas and during development |
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localizes to specific nuclear foci referred to as nuclear speckles in both cell lines and tissue (Nemos 2009) |
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localized both in nucleus and cytoplasm and, conversely to proliferating cells, did not undergo constitutive shuttling between these compartments  |
| basic FUNCTION
| having protein kinase, ATP binding activities |
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involved in protein amino acid phosphorylation |
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autophosphorylates (can self-associate and mediate the phosphorylation of its own TEY [Thr-Glu-Tyr] motif)and mediating the phosphorylation of the methyl-CpG-binding protein 2 (MECP2) |
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shuttles between the cytoplasm and the nucleus and the C-terminal tail is involved in localizing the protein to the cytoplasm in a mechanism depending on active nuclear export |
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regulates the dynamic behaviour of nuclear speckles, and controls nuclear speckle morphology probably by regulating the phosphorylation state of splicing regulatory proteins (Ricciardi 2009) |
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involved indirectly in pre-mRNA processing, by controlling splicing factor dynamics (Ricciardi 2009) |
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functional axis between MYCN and CDKL5 governing both neuron proliferation rate and differentiation |
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localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity |
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critical role of the palmitoylation-dependent CDKL5-DLG4 interaction in localizing CDKL5 to synapses for normal spine development |
