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FLASH GENE
Symbol CDKL3 contributors: mct/npt - updated : 30-06-2008
HGNC name cyclin-dependent kinase-like 3
HGNC id 15483
Location 5q31.1      Physical location : 133.634.115 - 133.702.765
Synonym name
  • rat serine/threonine kinase NKIATRE homolog
  • serine-threonine protein kinase NKIAMRE
  • serine/threonine protein kinase,cdc2-related kinase
  • Synonym symbol(s) NKIATRE, NKIAMRE
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 58.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1061 5q31.1 KIAA1061 protein HTGN29 5q31.1 HTGN29 protein VDAC1 5q31 voltage-dependent anion channel 1 TCF7 5q31.1 transcription factor 7 (T-cell specific, HMG-box) SKP1A 7q11.2 S-phase kinase-associated protein 1A (p19A) PPP2CA 5q23-q31 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform CDKL3 5q31 cyclin-dependent kinase-like 3 UBE2B 5q31 ubiquitin-conjugating enzyme E2B (RAD6 homolog) MGC13017 5q31.2 similar to RIKEN cDNA A430101B06 gene LOC391833 5 similar to 40S ribosomal protein S10 PHF15 5q31.2 PHD finger protein 15 SARA2 5q31.1 SAR1a gene homolog 2 (S. cerevisiae) SEC24A 5 SEC24 related gene family, member A (S. cerevisiae) CAMLG 5q23 calcium modulating ligand DDX46 5q31.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2138 - 592 - Haq, Dubos (2008)
    - splicing 1632 57 455 brain, nuclear Haq, Dubos (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    Visualeye    
    cell lineage hemopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • MAP kinase dual phosphorylation motif, Thr-Aspi-Tyr motif in kinase subdomain 8
  • a Thr-X-Tyr (TXY) motif in the activation loop domain
  • a nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila RKIALRE
    homolog to C.elegans KKIALRE
    intraspecies homolog to NKIAMRE (CDKL3)
    Homologene
    FAMILY
  • proline-directed kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • restricting cell growth or maintaining differentiation
  • may have a role in regulating cell growth and/or diferentiation
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • regulator of cell cycle progression
  • maintenance of normal hematopoiesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by by treatment of cells with phorbol 12-myristate 13-acetate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in mental retardation
    tumoral   deletion    
    in dysmyelopoiesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS