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FLASH GENE
Symbol CDKL2 contributors: - updated : 19-10-2004
HGNC name cyclin-dependent kinase-like 2 (CDC2-related kinase)
HGNC id 1782
Location 4q21.21      Physical location : 76.501.704 - 76.555.721
Synonym name
  • CDC2-related kinase
  • p56 KKIAMRE protein kinase
  • serine/threonine protein kinase KKIAMRE
    Synonym symbol(s) KKIAMRE, P56
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 51.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor) BTC 4q13-q21 betacellulin DKFZP564O0823 4q13.3-q21.3 DKFZP564O0823 protein FLJ23604 4q21.21 hypothetical protein FLJ23604 ZNF363 4q21.1 zinc finger protein 363 THAP6 4q21.21 THAP domain containing 6 FLJ23657 4q21.21 hypothetical protein FLJ23657 CDKL2 4q21.21 cyclin-dependent kinase-like 2 (CDC2-related kinase) G3BP2 4q12-q21.1 cyclin-dependent kinase-like 2 (CDC2-related kinase) VDP 4q21.1 vesicle docking protein p115 PPEF2 4q13-q21 protein phosphatase, EF hand calcium-binding domain 2 ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral lobefrontal 
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    MAP kinase dual phosphorylation motif (Thr-Asp-Tyr)
    HOMOLOGY
    interspecies homolog to rattus Kkialre,serine/threonine/kinase
    Homologene
    FAMILY CDC2-related serine/threonine protein kinases family
    CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a key role in the control of the eukaryotic cell cycle.
  • playing a role in learning and memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text sex differentiation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by treatement of cell with EGF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS