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FLASH GENE
Symbol CDKL2 contributors: - updated : 19-10-2004
HGNC name cyclin-dependent kinase-like 2 (CDC2-related kinase)
HGNC id 1782
Location 4q21.21      Physical location : 76.501.704 - 76.555.721
Synonym name
  • CDC2-related kinase
  • p56 KKIAMRE protein kinase
  • serine/threonine protein kinase KKIAMRE
    Synonym symbol(s) KKIAMRE, P56
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 51.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral lobefrontal 
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    MAP kinase dual phosphorylation motif (Thr-Asp-Tyr)
    HOMOLOGY
    interspecies homolog to rattus Kkialre,serine/threonine/kinase
    Homologene
    FAMILY CDC2-related serine/threonine protein kinases family
    CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a key role in the control of the eukaryotic cell cycle.
  • playing a role in learning and memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text sex differentiation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by treatement of cell with EGF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS