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FLASH GENE
Symbol CDKL1 contributors: npt/ - updated : 26-03-2008
HGNC name cyclin-dependent kinase-like 1 (CDC2-related kinase)
HGNC id 1781
Location 14q22.1      Physical location : 50.796.720 - 50.862.617
Synonym name
  • CDC2-related kinase 1
  • serine/threonine protein kinase KKIALRE
  • protein kinase p42 KKIALRE
  • Synonym symbol(s) KKIALRE, P42
    EC.number 2.7.11.22, 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 65.90 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387988 14 hypothetical gene supported by BC015974 RPS29 14q13.3-q21.1 ribosomal protein S29 PPIL5 14q21.3 peptidylprolyl isomerase (cyclophilin) like 5 ARHQP 14 ras homolog gene family, member Q pseudogene RPL36AL 14q21 ribosomal protein L36a-like MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase C14orf104 14q21.3 chromosome 14 open reading frame 104 POLE2 14q21-q22 polymerase (DNA directed), epsilon 2 (p59 subunit) STK16P 14 serine/threonine kinase 16 pseudogene KLHDC1 14q21.3 kelch domain containing 1 KLHDC2 14q21.3 kelch domain containing 2 SDCCAG1 14q22 serologically defined colon cancer antigen 1 ARF6 7q22.1 ADP-ribosylation factor 6 LOC283551 14q22.1 hypothetical protein LOC283551 PDLIM1P 14 PDZ and LIM domain 1 pseudogene RPS15AP2 14 ribosomal protein S15a pseudogene 2 LOC196913 14q22.1 hypothetical protein LOC196913 C14orf138 14q22.1 chromosome 14 open reading frame 138 SOS2 14q22 son of sevenless homolog 2 (Drosophila) C14orf160 14q22.1 chromosome 14 open reading frame 160 ATP5S 14q21.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) CDKL1 14q22.1 cyclin-dependent kinase-like 1 (CDC2-related kinase) MAP4K5 14q13.2-q21 mitogen-activated protein kinase kinase kinase kinase 5 SPG3A 14q21.3 spastic paraplegia 3A (autosomal dominant) SNRPGP 14 small nuclear ribonucleoprotein polypeptide G pseudogene SAV1 14q13-q23 salvador homolog 1 (Drosophila) ZNF405P 14 zinc finger protein 405 pseudogene NIN 14q21.3-q22 ninein (GSK3B interacting protein) C14orf29 14q21.3 chromosome 14 open reading frame 29 PYGL 14q21.2 phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) MRP63P9 14q22.1 mitochondrial ribosomal protein 63 pseudogene 9 TRIM9 14q21.3 tripartite motif-containing 9
    RNA
    TRANSCRIPTS type messenger
    text four or five isoforms in brain
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1177 41.7 358 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Nervousbrain    
    Reproductivefemale systemovary   
    Visualeyelens   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • MAP kinase dual phosphorylation motif (Thr-Asp-Tyr)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in protein amino acid phosphorylation and regulation of cell cycle
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by treatment of cells with EGF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS