basic FUNCTION
| acting as a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes |
|
functioning as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery |
|
recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors |
|
phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex |
|
phosphorylating CCNH leading to down-regulation of the TFIIH complex and transcriptional repression |
|
recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation |
|
CDK8/cyclin C can regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH |
|
CDK8 functions as a positive regulator of p21 and HDM2 transcription |
|
CDK8 kinase activity is necessary for beta-catenin-driven transformation and for expression of several beta-catenin transcriptional targets |
|
CDK8 is a histone H3 kinase, when associated with Mediator |
|
CDK8 plays important roles in gene regulation and is a colorectal cancer oncogene that regulates b-catenin activity |
|
functioning as a coactivator within the TP53 transcriptional program |
|
with CDK11B possess opposing functions in viral activator VP16-dependent transcriptional regulation |
|
stimulus-specific positive coregulator of TP53 target genes |
|
role for CDK8 in transcriptional regulation that may contribute to its oncogenic effects |
|
involved in the regulation of mRNA transcription and was identified as a potent oncogene in colon cancerogenesis |
|
CDK8 inhibits Notch acetylation and Notch transcription enhanced by EP300 |
|
CDK8 supported transcriptional activation, whereas CDK19, however, counteracted it |
|
cyclin-dependent kinase that mediates transcriptional control of pathways linked to both cancer and stem cells |
|
enzymatically active CDK8 is responsible for suppression of GLI3 transactivation activity, and further, MED12 most likely contributes to this suppression through its role as an anchor for CDK8 in Mediator |
|
functions as an oncoprotein in melanoma and colorectal cancers, but plays a tumor-suppressive role in endometrial cancers |
|
implicated as a regulator of multiple steps in cell cycle progression |
|
mediator-associated kinase required for induction of many HIF1A target genes |
|
CDK8 module could positively regulate transcription by modulating Mediator conformation |
|
has emerged as a key regulator of multiple transcriptional programs linked to nutrient/growth factor sensing and differentiation control |
|
CDK8 functions to suppress de novo lipogenesis, that is often elevated in non-alcoholic fatty liver disease (NAFLD) and insulin resistance |
|
CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network |
|
function for CDK8 and CDK19 in regulating innate immune activation,suggesting that these kinases may warrant consideration as therapeutic targets for inflammatory disorders |
|
CDK8 and its paralog CDK19, associated with the transcriptional Mediator complex, act as coregulators of several transcription factors implicated in cancer |
|
selective role of CDK8/19 identifies these kinases as mediators of transcriptional reprogramming, a key aspect of development and differentiation as well as pathological processes |
|
CDK8 activates or represses transcription by associating with the mediator complex or by regulating transcription factors |
|
suppressive effect of CDK8 on NK-cell activity |
|
regulates transcriptional process via associating with the mediator complex or phosphorylating transcription factors (TF) |
|
CDK8 and CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming |