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FLASH GENE
Symbol CDK5RAP3 contributors: mct/npt/pgu - updated : 09-05-2017
HGNC name CDK5 regulatory subunit associated protein 3
HGNC id 18673
Location 17q21.32      Physical location : 46.048.428 - 46.059.146
Synonym name
  • CDK5 activator-binding protein C53
  • HSF-27 protein
  • ischemic heart CDK5 activator-binding protein C53
  • LXXLL/leucine-zipper-containing ARF binding protein
  • Synonym symbol(s) C53, IC53, HSF-27, MST016, FLJ13660, OK/SW-c/114, PP1553, LZAP
    DNA
    TYPE functioning gene
    STRUCTURE 10.72 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase MGC11242 17q21.32 hypothetical protein MGC11242 CDK5RAP3 17q21.2 CDK5 regulatory subunit associated protein 3 COPZ2 17q21.3 coatomer protein complex, subunit zeta 2 NFE2L1 17q21.3 nuclear factor (erythroid-derived 2)-like 1 CBX1 17q21.32 chromobox homolog 1 (HP1 beta homolog Drosophila ) SNX11 17q21.2 sorting nexin 11 SCAP1 17q21.32 src family associated phosphoprotein 1 HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1884 - 506 - 2007 17549666
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila CG4826
    Homologene
    FAMILY
  • CDK5RAP3 family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in the regulation of cell proliferation
  • regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
  • having TP53-dependent cell-cycle effects that are independent of ARF
  • inhibit cellular proliferation and clonogenic growth
  • playing a role in NF-kappaB regulation and tumor suppression
  • potentiates DNA damage-induced cell death by modulating the G2/M checkpoint
  • novel negative regulator of checkpoint response, and by counteracting CHEK1, promotes CDC2 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response
  • putative tumor suppressor that plays important roles in multiple cell signaling pathways, including DNA damage response and NF-kappaB signaling
  • UFL1, like CDK5RAP3, also plays an important role in regulation of NF-kappaB signaling and cell invasion
  • putative tumor suppressor that inhibits RELA, CHEK1 and CHEK2 and activates TP53
  • its activity includes inhibition of MAPK14 phosphorylation and activation
  • CDK5RAP3 binding to the substrate is not required for potentiated PPM1D catalytic activity and directly binds PPM1D to augment its phosphatase activity
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component components of the UFM1 conjugation pathway (UFM1, DDRGK1, UFL1 and CDK5RAP3)
  • CDK5RAP3 and UFL1 may form a large protein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the CDK5 activator p35
  • interacts with endogenous ARF (can regulate ARF biochemical and biological activity)
  • regulator of CDC2 activation
  • interacts with CHEK1 and antagonizes its function
  • binds MAPK14, alters its cellular localization, and inhibits basal and cytokine-stimulated MAPK14 activity
  • CDK5RAP3 binds PPM1D and stimulates its phosphatase activity
  • cell & other
    REGULATION
    Other phosphorylated by NCLK
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CCNB2, AGER, CDK5RAP3, may be used as a very reliable biomarker of lung adenocarcinoma
  • Therapy target
    ANIMAL & CELL MODELS