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FLASH GENE
Symbol CDK5RAP3 contributors: mct/npt/pgu - updated : 09-05-2017
HGNC name CDK5 regulatory subunit associated protein 3
HGNC id 18673
Location 17q21.32      Physical location : 46.048.428 - 46.059.146
Synonym name
  • CDK5 activator-binding protein C53
  • HSF-27 protein
  • ischemic heart CDK5 activator-binding protein C53
  • LXXLL/leucine-zipper-containing ARF binding protein
  • Synonym symbol(s) C53, IC53, HSF-27, MST016, FLJ13660, OK/SW-c/114, PP1553, LZAP
    DNA
    TYPE functioning gene
    STRUCTURE 10.72 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1884 - 506 - 2007 17549666
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila CG4826
    Homologene
    FAMILY
  • CDK5RAP3 family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in the regulation of cell proliferation
  • regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
  • having TP53-dependent cell-cycle effects that are independent of ARF
  • inhibit cellular proliferation and clonogenic growth
  • playing a role in NF-kappaB regulation and tumor suppression
  • potentiates DNA damage-induced cell death by modulating the G2/M checkpoint
  • novel negative regulator of checkpoint response, and by counteracting CHEK1, promotes CDC2 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response
  • putative tumor suppressor that plays important roles in multiple cell signaling pathways, including DNA damage response and NF-kappaB signaling
  • UFL1, like CDK5RAP3, also plays an important role in regulation of NF-kappaB signaling and cell invasion
  • putative tumor suppressor that inhibits RELA, CHEK1 and CHEK2 and activates TP53
  • its activity includes inhibition of MAPK14 phosphorylation and activation
  • CDK5RAP3 binding to the substrate is not required for potentiated PPM1D catalytic activity and directly binds PPM1D to augment its phosphatase activity
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component components of the UFM1 conjugation pathway (UFM1, DDRGK1, UFL1 and CDK5RAP3)
  • CDK5RAP3 and UFL1 may form a large protein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the CDK5 activator p35
  • interacts with endogenous ARF (can regulate ARF biochemical and biological activity)
  • regulator of CDC2 activation
  • interacts with CHEK1 and antagonizes its function
  • binds MAPK14, alters its cellular localization, and inhibits basal and cytokine-stimulated MAPK14 activity
  • CDK5RAP3 binds PPM1D and stimulates its phosphatase activity
  • cell & other
    REGULATION
    Other phosphorylated by NCLK
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CCNB2, AGER, CDK5RAP3, may be used as a very reliable biomarker of lung adenocarcinoma
  • Therapy target
    ANIMAL & CELL MODELS