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FLASH GENE
Symbol CDK5RAP2 contributors: mct - updated : 08-03-2010
HGNC name CDK5 regulatory subunit associated protein 2
HGNC id 18672
Corresponding disease
MCPH3 microcephaly primary 3
Location 9q33.2      Physical location : 123.151.147 - 123.342.437
Synonym name
  • CDK5 activator-binding protein C48
  • centrosome-associated protein 215
  • Synonym symbol(s) C48, FLJ10867, KIAA1633, CEP215, DKFZp686B1070, DKFZp686D1070
    DNA
    TYPE functioning gene
    STRUCTURE 191.29 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC347165 9q33.3 similar to beta-tubulin 4Q DBC1 9q32-q33 deleted in bladder cancer 1 CDK5RAP2 9q33.3 CDK5 regulatory subunit associated protein 2 LOC389788 9 similar to EGFL5 LOC392387 9 similar to Ahcy protein FBXW2 9q34 F-box and WD-40 domain protein 2 PSMD5 9q33.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 PHF19 9q34.11 PHD finger protein 19 TRAF1 9q33-q34 TNF receptor-associated factor 1 C5 9q33 complement component 5 CEP1 9q33 centrosomal protein 1 RAB14 9q32-q34.11 RAB14, member RAS oncogene family LOC392388 9 similar to vacuolar H+-ATPase B subunit GSN 9q33.3 gelsolin (amyloidosis, Finnish type) MOST2 9q34.11 MOST2 protein STOM 9q34.1 stomatin a1/3GTP 9q34.11 alpha-1,3-galactosyltransferase pseudogene DAB2IP 9q33.1-q33.3 DAB2 interacting protein LOC158135 9q34.11 similar to H23L24.3.p NDUFA8 9q32.4-q34.41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa FLJ46909 9q34.11 FLJ46909 protein LHX6 9q34.11 LIM homeobox 6 MGC2734 MRRF 9q33-q34.1 mitochondrial ribosome recycling factor PTGS1 9q32-q33.3 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) LOC347168 9q34.11 similar to Olfactory receptor 1J1 OR1J5 9q34.11 olfactory receptor, family 1, subfamily J, member 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 6230 215 1893 - 2005 15793586
    37 splicing 5993 - 1814 - 2005 15793586
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicorpus callosum  
     brainlimbic systemhippocampus  
     braindiencephalonthalamus  
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier liningneuroepithelium  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • centrosome and Golgi-targeting domains in the C-terminal region with its core region highly homologous to the Motif 2 (CM2) of centrosomin (EIF3A)(CM2-like motif is essential for the association of the centrosome-targeting domain to pericentrin and AKAP9)
  • multiple coiled-coil domains
  • a gamma-tubulin complex (g-TuC)-binding domain conserved
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila CG3571
    homolog to C.elegans T27E9.4a
    ortholog to murine Cdk5rap2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • to the spindle poles of mitotic cells
  • also localizes at the midbody ring
  • localizes to microtubules and concentrates at the distal tips in addition to centrosomal localization
  • in somatic cells, CDK5RAP2 localizes throughout the pericentriolar material in all stages of the cell cycle
  • localizes to the Golgi complex in an ATP- and centrosome-dependent manner and associates with Golgi membranes independently of microtubules
  • basic FUNCTION
  • potential regulator of CDK5 activity via its interaction with CDK5R1
  • functionally interacts with pericentrin, suggesting that both proteins influence centrosome cohesion through an indirect mechanism related to cytoskeletal dynamics
  • pericentriolar structural component that functions in gamma-tubulin ring complex attachment and therefore in the microtubule organizing function of the centrosome
  • targets growing microtubule tips in association with ANKS1B to regulate microtubule dynamics
  • required for spindle checkpoint function and is a common target in paclitaxel and doxorubicin resistance
  • may undertake a conserved mechanism for centrosomal localization
  • involved in the centrosomal attachment of gamma-tubulin and centrosome cohesion
  • may act in the attachment of gamma-tubulin complexes to, and microtubule nucleation at, the Golgi complex
  • stimulates microtubule nucleation by the gamma-tubulin ring complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CDK5RAP2-ANKS1B complex regulates microtubule dynamics and stability
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CDK5 (phosphorylated by Cdk5 kinase)
  • associates with centrosomes throughout the cell cycle and does not appear to interact with CEP68, CEP250 or CROCC
  • interacts directly with ANKS1B, a prototypic member of microtubule plus-end tracking proteins, and contains the basic and Ser-rich motif responsible for ANKS1B binding
  • may associate with multiple proteins on the centrosomes
  • interacts with SPAG5 and CEP72
  • CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome, and they interact to promote centriole duplication
  • cell & other
    REGULATION
    Other phosphorylated by NCLK
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS