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FLASH GENE
Symbol CDK5RAP1 contributors: - updated : 21-08-2007
HGNC name CDK5 regulatory subunit associated protein 1
HGNC id 15880
Location 20pter-q11.23      Physical location : 31.946.646 - 31.989.337
Synonym name
  • hematopoietic stem/progenitor cells 167
  • chromosome 20 open reading frame 34
  • CDK5 activator-binding protein C42
  • Synonym symbol(s) C42, CGI-05, HSPC167, C20orf34, LOC51654
    DNA
    TYPE functioning gene
    STRUCTURE 42.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2104 - 587 - Ching, Lehner
    - splicing 1944 - 497 - Ching, Lehner
    - - 1923 - 574 widely expressed, relatively high in placenta and lung, whereas low levels of expression were detected in heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, small intestine and peripheral blood leukocytes Zou
    - - 1792 - 426 mainly expressed in brain, placenta and testis Zou
  • lacked 1 exon
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  highly
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
     tonsils   highly
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the uncharacterized domain UPF0004
  • TRAM domain
  • C-terminal fragment bound with high affinity but was not inhibitory
  • HOMOLOGY
    interspecies homolog to Drosophila CG7187
    Homologene
    FAMILY
  • CDK5RAP1 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION involved in the regulation of neuronal differentiation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CDK5
  • interacts with CDK5R1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS