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Symbol CDK2AP2 contributors: mct - updated : 11-02-2016
HGNC name CDK2-associated protein 2
HGNC id 30833
Location 11q13.2      Physical location : 67.273.968 - 67.276.102
Synonym name
  • DOC-1-related protein
  • tumor suppressor deleted in oral cancer related 1
  • Synonym symbol(s) DOC-1R, p14
    DNA
    TYPE functioning gene
    STRUCTURE 2.24 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1499 - 126 - 1999 10082655
    4 - 1099 - 71 - 1999 10082655
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Cdk2ap2
    Homologene
    FAMILY DOC1 family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • tumor suppressor activity
  • CDK2AP2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation
  • CDK2AP2 overexpression inhibited G1/S phase transition, DNA replication and suppressed CDK2 activity
  • antitumor effects of CDK2AP2 may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 expression and activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative regulator of CDK2 activity
  • CDK2AP1 has two putative binding partners: CDK2AP2 and CDK2
  • CDK2AP2 associated with CDK2 and inhibited CDK2 activation by obstructing its association with cyclin E and A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS