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FLASH GENE
Symbol CDK17 contributors: mct - updated : 14-09-2011
HGNC name cyclin-dependent kinase 17
HGNC id 8750
Location 12q23.1      Physical location : 96.672.041 - 96.794.366
Synonym name
  • protein kinase cdc2-related PCTAIRE-2
  • serine/threonine-protein kinase PCTAIRE-2
  • PCTAIRE-motif protein kinase 2
  • Synonym symbol(s) PCTAIRE2, PCTK2
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    STRUCTURE 122.18 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4194 59.4 523 - 2000 10727952
    - - 4722 59.4 523 - 2000 10727952
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunelymph node   highly
     spleen   predominantly
    Nervousbrainforebraincerebral cortex   Homo sapiens
     brainhindbraincerebellum   Homo sapiens
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Pctk2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in terminally differentiated neurons
  • acting as a Ser/Thr-phosphorylating for histone H1
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    text regulation of cell cycle
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CABLES1, CDK16 and TDRD7
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • TDRD7 associates with the N-terminal domain of PCTAIRE 2 (CDK17) through its C-terminal domain which contains two tudor-like domains, and is a physiological partner of CDK17 in terminally differentiated neurons
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS