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FLASH GENE
Symbol CDK16 contributors: mct - updated : 07-02-2014
HGNC name cyclin-dependent kinase 16
HGNC id 8749
Location Xp11.3      Physical location : 47.077.527 - 47.089.392
Synonym name
  • PCTAIRE protein kinase 1
  • PCTAIRE-motif protein kinase 12
  • serine/threonine-protein kinase
  • cell division protein kinase 16
  • Synonym symbol(s) PCTK1, PCTAIRE, PCTAIRE1, PCTGAIRE, FLJ16665
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text escaping inactivation in human
    STRUCTURE 11.95 kb     16 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 3169 55.6 496 - 2012 22184064
    16 splicing 3280 56.2 502 - 2012 22184064
    16 - 3034 63.3 570 - 2012 22184064
    - - 2987 51 448 - 2012 22184064
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine/threonine protein kinase, PCTAIRE motif
  • a conserved catalytic domain flanked by N- and C-terminal extensions that are involved in cyclin binding
  • HOMOLOGY
    interspecies homolog to cdc2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • BRSK2 co-localizes with CDK16 in the cytoplasm and phosphorylates one of its serine residues, Ser-12
  • by binding to N-myristoylated CCNY, CDK16 is targeted to the plasma membrane
  • basic FUNCTION
  • may be playing a role in signal transduction cascades in terminally differentiated cells
  • is a membrane-targeted CDK essential for spermatogenesis
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with YWHAH, YWHAZ
  • interacting with CDK5 in muscle
  • regulates neurotransmitter release through phosphorylation of NSF, and its kinase activity is regulated by the CDK5-dependent phosphorylation at Serine-95 (Ser95) (PMI: 21335063)
  • CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PRKACA phosphorylation site
  • BRSK2 interacts with CDK-related protein kinase CDK16, a kinase involved in neurite outgrowth and neurotransmitter release
  • cell & other
    REGULATION
    Other regulated by phosphorylation-controlled cyclin binding
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice lacking CDK16 developed normally, but male mice were infertile