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FLASH GENE
Symbol CDK14 contributors: np/ - updated : 30-06-2007
HGNC name cyclin-dependent kinase 14
HGNC id 8883
Location 7q21.13      Physical location : 90.338.711 - 90.839.904
Synonym name
  • PFTAIRE protein kinase 1
  • serine/threonine-protein kinase PFTAIRE-1
  • cell division protein kinase 14
    • Synonym symbol(s) PFTAIRE1, KIAA0834, PFTK1
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    STRUCTURE 501.19 kb     14 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4953 - 451 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tyrosine kinase, catalytic domain
    • HOMOLOGY
    interspecies homolog to murine pftk1
    intraspecies homolog to cdc2 kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
    • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting as a cyclin-dependent kinases that regulates cell cycle progression and cell proliferation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formed a ternary complex with the cell cycle inhibitor CDKN1A in cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacted with cyclin D3 (CCND3)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS