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FLASH GENE
Symbol CDK12 contributors: mct - updated : 26-03-2014
HGNC name cyclin-dependent kinase 12
HGNC id 24224
Location 17q12      Physical location : 37.617.738 - 37.690.799
Synonym name
  • CDC2-related protein kinase 7
  • cell division cycle 2-related protein kinase 7
  • Cdc2-related kinase, arginine/serine-rich
  • Synonym symbol(s) CRK7, KIAA0904, CRKR, CRKRS
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    STRUCTURE 73.06 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 8310 164 1490 - -
    14 - 8283 163.1 1481 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervecranial nerveoptic nerve  
    Reproductivefemale systemovary   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an arginine/serine-rich (RS) domain (CrkRS, predominantly found in splicing factors) closely related to the cyclin-dependent kinase (CDK) family
  • extensive proline-rich regions that match the consensus for SH3 and WW domain binding sites
  • HOMOLOGY
    Homologene
    FAMILY
  • kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be a novel, conserved link between the transcription and splicing machinery
  • acting as a protein serine threonine kinase
  • CDC2-related protein kinase containing an arginine- and serine-rich (SR) domain, a characteristic of the SR protein family of splicing factors, and may be involved in RNA processing
  • CELLULAR PROCESS nucleotide, transcription
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cyclin-dependent kinase and cyclin partner of CCNL1 and regulate alternative splicing
  • interaction of CDK12 with CCNK is required for the phosphorylation of the C-terminal domain of RNA polymerase II
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS