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FLASH GENE
Symbol CDK11A contributors: mct/pgu - updated : 27-06-2016
HGNC name cyclin-dependent kinase 11A
HGNC id 1730
Location 1p36.33      Physical location : 1.634.171 - 1.655.791
Synonym name
  • cell division cycle 2-like 2
  • CDC2 related kinase p58
  • galactosyltransferase-associated protein kinase p58/GTA
  • cyclin-dependent kinase 11
  • cell division cycle 2-like 2 (PITSLRE proteins)
  • Synonym symbol(s) PITSLREA, CDC2L3, p58GTA, PITSLRE, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, CDK11, CDC2L2, MGC131975, PITSLREB
    EC.number 2.7.11.22
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation, tail to tail
    text close to CDC2L1
    STRUCTURE 21.62 kb     20 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • proximal promoter of the Cdc2L2 gene GC rich and not containing TATA and CAAT boxes
  • multiple consensus and near consensus transcription factor binding sites, such as two Ets-1, one cAMP-responsive element (CRE) and one TCF11/LCR-F1/Nrf1 binding sites
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2448 - 780 - 1994 8195233
  • also called variant 5/isoform 5
  • same isoform than variant 8
  • - splicing 2436 90.7 776 - 1994 8195233
    also called variant 3/isoform 3
    20 splicing 2620 - 770 - 2007 17606997
    also called ariant 4/isoform 4
    20 splicing 2650 110 780 expressed at constant levels during the cell cycle 2007 17606997
  • also called variant 1 or p110
  • contains an IRES (internal ribosome entry site) that allows the expression of a smaller p58(PITSLRE) isoform during the G2/M stage of the cell cycle
  • involved in transcription and RNA processing
  • - splicing 2471 90.7 777 - 1994 8195233
  • also called variant 8/isoform 8
  • same isoform than variant 1
  • - splicing 2465 90.7 775 - 1994 8195233
    also called variant 9/isoform 9
    - splicing 1767 58 439 expressed only during G2 and M phases 2006 16462731
  • also called p58, variant 10/isoform 10
  • specifically translated from an internal ribosome entry site sequence during G2/M
  • involved in centrosome maturation and spindle morphogenesis (Hu 2007)
  • also required for sister chromatid cohesion and the completion of mitosis (Hu 2007)
  • role in centrosome maturation and bipolar spindle morphogenesis.
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary  highly
    Respiratorylung    
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    life cycle division
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a helicase ATP-binding domain
  • a helicase c-terminal domain
  • HOMOLOGY
    interspecies homolog to Drosophila Pitslre
    homolog to C.elegans B0495.2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , receptor serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing roles in cell apoptosis
  • a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
  • exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
  • role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
  • interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
  • CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
  • CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
  • involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    constitutional     --low  
    caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death
    Susceptibility to type 2 diabetes in a Han Chinese cohort
    Variant & Polymorphism SNP SNP11 strongly associated with female patients with T2D
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS