Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDK10 contributors: mct - updated : 17-10-2017
HGNC name cyclin-dependent kinase (CDC2-like) 10
HGNC id 1770
Corresponding disease
ALKAS Al Kaissi syndrome
Location 16q24.3      Physical location : 89.753.075 - 89.762.771
Synonym symbol(s) CDC2R1, PISSLRE, ALKAS,
EC.number 2.7.11.22
DNA
TYPE functioning gene
STRUCTURE 9.75 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure several initiation sites
MAPPING cloned Y linked N status confirmed
Map cen - D16S422 - D16S402 - D16S520 - COX4I1 - D16S413 - CDK10 - FANCA FANCA - MC1R - qter
Authors GeneMap (98)
RNA
TRANSCRIPTS type messenger
text several complex alternatively spliced isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 initiation site 1815 41 360 - 2001 11313931
13 splicing 1643 - 272 2001 11313931
13 - 1777 - 289 - 2001 11313931
13 - 1759 - 283 - 2001 11313931
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PSTAIRE-like motif (PISSLRE)
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae cdc28
intraspecies homolog to cyclin dependent kinase (CDC2-like) related protein kinase
Homologene
FAMILY
  • serine/threonine family of protein kinases
  • Cdc2 family of kinases
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase
  • acting in G2 phase of the cell cycle
  • important determinant of resistance to endocrine therapy for breast cancer
  • critical function in neurogenesis by modulation of RAF1 expression
  • is a protein kinase that controls ETS2 degradation
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CDK10/CCNQ is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RHOA signaling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALKAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancers and correlates with disease progression and poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a prognostic biomarker for breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    potential therapeutic target for biliary tract cancer cells
    ANIMAL & CELL MODELS
  • homozygous Cdk10-knockout mice died postnatally with severe growth retardation, skeletal defects, and kidney and lung abnormalities